DHR96 核受体控制果蝇中的三酰基甘油动态平衡。
The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.
机构信息
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112-5330, USA.
出版信息
Cell Metab. 2009 Dec;10(6):481-90. doi: 10.1016/j.cmet.2009.10.010.
Abstract
Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily.
摘要
三酰基甘油 (TAG) 稳态是正常生理的一个组成部分，对适当的能量代谢至关重要。在这里，我们表明，PXR 和 CAR 核受体的果蝇直系同源物 DHR96 在 TAG 稳态中起着重要作用。DHR96 突变体对饥饿敏感，脂肪体和中肠中的 TAG 水平降低，并且对饮食诱导的肥胖有抗性，而 DHR96 过表达导致对饥饿的抗性和 TAG 水平的增加。我们表明，DHR96 功能在中肠中对膳食脂肪的分解是必需的，它通过 CG5932 胃脂肪酶发挥这种作用，CG5932 胃脂肪酶对 TAG 稳态至关重要。这项研究提供了对果蝇饮食脂肪代谢调节的深入了解，并表明脂质代谢的调节是 PXR/CAR/DHR96 核受体亚家族的一个古老功能。
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