从蠕虫到人：通过模式生物了解肠道脂质代谢。
From worms to humans: Understanding intestinal lipid metabolism via model organisms.
机构信息
Department of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States.
Department of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Apr;1868(4):159290. doi: 10.1016/j.bbalip.2023.159290. Epub 2023 Feb 3.
Abstract
The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circulatory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus. Understanding the molecular response of intestinal cells to dietary lipid has the potential to undercover novel therapies to combat metabolic syndrome.
摘要
肠道负责在膳食脂质进入循环系统之前进行有效的吸收和包装。本综述全面概述了不同模式生物的肠上皮细胞如何吸收膳食脂质，然后分泌最大类别的脂蛋白（乳糜微粒）以满足每种动物的独特需求。我们讨论了饮食与代谢性疾病进展（特别是 2 型糖尿病）之间的假定关系。了解肠道细胞对膳食脂质的分子反应有可能为治疗代谢综合征提供新的治疗方法。
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