Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Neurosci Lett. 2010 Jan 18;469(1):102-6. doi: 10.1016/j.neulet.2009.11.053. Epub 2009 Nov 27.
Attention-deficit/hyperactivity disorder (ADHD) in children is characterized by elevated levels of slow wave activity and reduced fast wave activity in resting-state electroencephalogram (EEG). In adults with ADHD, resting-state EEG findings are scarce and inconsistent. The present study examined whether the disparate findings are due EEG recording conditions (i.e., eyes-open vs. eyes-closed). A second goal of the current study was to assess relations between EEG spectral indices to performance measures obtained using a stop-signal task, and to behavioral ADHD symptoms. The present study included 24 adults with ADHD and 24 control adults. The EEG results showed a greater reduction in alpha power from eyes-closed to eyes-open (i.e., alpha attenuation) in ADHD compared to controls. In addition, theta/beta ratio was negatively correlated to the speed of responding to choice stimuli. These findings were interpreted vis-à-vis a biophysical model assuming that the hypo-arousal in ADHD is due to an overdrive of the nucleus coeruleus resulting in inhibitory activity of the thalamic reticular nucleus.
儿童注意缺陷多动障碍（ADHD）的特征是静息状态脑电图（EEG）中慢波活动水平升高和快波活动减少。在患有 ADHD 的成年人中，静息状态 EEG 的发现很少且不一致。本研究探讨了这些不同的发现是否是由于 EEG 记录条件（即睁眼与闭眼）引起的。本研究的第二个目标是评估 EEG 频谱指标与使用停止信号任务获得的绩效测量之间的关系，以及与行为 ADHD 症状的关系。本研究包括 24 名 ADHD 成年患者和 24 名对照成年患者。脑电图结果显示，与对照组相比，ADHD 患者从闭眼到睁眼时的 alpha 功率（即 alpha 衰减）降低幅度更大。此外，theta/beta 比值与对选择刺激的反应速度呈负相关。这些发现是根据假设 ADHD 中低唤醒是由于蓝斑核过度驱动导致丘脑网状核抑制活动的生物物理模型来解释的。
