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经颅交流电刺激对成人注意力缺陷多动障碍的α波调制

Alpha modulation via transcranial alternating current stimulation in adults with attention-deficit hyperactivity disorder.

作者信息

Kannen Kyra, Rasbach Johanna, Fantazi Amin, Wiebe Annika, Selaskowski Benjamin, Asché Laura, Aslan Behrem, Lux Silke, Herrmann Christoph S, Philipsen Alexandra, Braun Niclas

机构信息

Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.

Experimental Psychology Lab, Department of Psychology, University of Oldenburg, Oldenburg, Germany.

出版信息

Front Psychol. 2024 Jan 12;14:1280397. doi: 10.3389/fpsyg.2023.1280397. eCollection 2023.

DOI:10.3389/fpsyg.2023.1280397
PMID:38282845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10812111/
Abstract

BACKGROUND

One potential therapy treating attention-deficit/hyperactivity disorder (ADHD) is to modulate dysfunctional brain activations using brain stimulation techniques. While the number of studies investigating the effect of transcranial direct current stimulation on ADHD symptoms continues to increase, transcranial alternating current stimulation (tACS) is poorly examined. Previous studies reported impaired alpha brain oscillation (8-12 Hz) that may be associated with increased attention deficits in ADHD. Our aim was to enhance alpha power in adult ADHD patients via tACS, using different methods to explore potential therapeutic effects.

METHODS

Undergoing a crossover design, adults with ADHD received active and sham stimulation on distinct days. Before and after each intervention, mean alpha power, attention performance, subjective symptom ratings, as well as head and gaze movement were examined.

RESULTS

Frequency analyses revealed a significant power increase in the alpha band after both interventions. Despite a trend toward an interaction effect, this alpha power increase was, however, not significantly higher after active stimulation compared to sham stimulation. For the other measures, some additional pre-post effects were found, which were not intervention-related.

CONCLUSION

Our study cannot provide clear evidence for a tACS-induced increase in alpha power in adult ADHD patients, and thus no stimulation related improvement of attention parameters. We provide further recommendations for the future investigation of tACS as a potential ADHD treatment.

摘要

背景

治疗注意力缺陷多动障碍（ADHD）的一种潜在疗法是使用脑刺激技术调节功能失调的大脑激活。虽然研究经颅直流电刺激对ADHD症状影响的研究数量不断增加，但经颅交流电刺激（tACS）的研究却很少。先前的研究报告称，α脑振荡（8-12Hz）受损可能与ADHD患者注意力缺陷增加有关。我们的目的是通过tACS增强成年ADHD患者的α波功率，采用不同方法探索潜在治疗效果。

方法

采用交叉设计，成年ADHD患者在不同日期接受主动刺激和假刺激。每次干预前后，检测平均α波功率、注意力表现、主观症状评分以及头部和注视运动。

结果

频率分析显示，两种干预后α波段功率均显著增加。尽管存在交互效应趋势，但与假刺激相比，主动刺激后α波功率增加并不显著更高。对于其他测量指标，发现了一些额外的前后效应，但与干预无关。

结论

我们的研究无法为tACS诱导成年ADHD患者α波功率增加提供明确证据，因此也无法证明刺激与注意力参数改善有关。我们为未来将tACS作为ADHD潜在治疗方法的研究提供了进一步建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/08ebc87b88c7/fpsyg-14-1280397-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/d84ddebcb858/fpsyg-14-1280397-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/6b20ad1faf73/fpsyg-14-1280397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/08ebc87b88c7/fpsyg-14-1280397-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/d84ddebcb858/fpsyg-14-1280397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/a0a553de8ab1/fpsyg-14-1280397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/730d108cc1e9/fpsyg-14-1280397-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7718/10812111/08ebc87b88c7/fpsyg-14-1280397-g007.jpg

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