DNA 损伤反应、组蛋白修饰和血管新生之间的串扰。
Crosstalk between the DNA damage response, histone modifications and neovascularisation.
机构信息
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Int J Biochem Cell Biol. 2010 Feb;42(2):193-7. doi: 10.1016/j.biocel.2009.11.020. Epub 2009 Nov 27.
Abstract
Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.
摘要
血管新生在多种恶性和炎症性疾病以及眼部疾病的发病过程中起着关键作用。在新血管形成过程中，内皮细胞的功能（如增殖和发芽）非常重要，并且受到多种生长因子的调节。DNA 损伤反应机制以及调节组蛋白修饰的因子，如组蛋白去乙酰化酶，调节细胞命运和基因表达。最近的证据表明，BRCA1、H2AX 和 SIRT1 之间可能存在相互作用，这些相互作用存在于这些细胞内途径和血管新生中，本文将对此进行综述。
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