Fraisl Peter, Mazzone Massimiliano, Schmidt Thomas, Carmeliet Peter
Vesalius Research Center, Leuven, Belgium.
Dev Cell. 2009 Feb;16(2):167-79. doi: 10.1016/j.devcel.2009.01.003.
Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regarding the emerging crosstalk between angiogenesis and metabolism. We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism.
血管通过为所有细胞输送氧气和营养物质，在环境与生物体之间形成了一个重要的界面，从而决定细胞代谢。因此，氧气和代谢影响血管网络的发育也就不足为奇了。在这里，我们讨论关于血管生成与代谢之间新出现的相互作用的最新见解。我们将重点介绍氧气和代谢如何调节血管生成，以及血管生成因子如何反过来调节代谢方面的进展。
