Peyromaure M, Valéri A, Rebillard X, Beuzeboc P, Richaud P, Soulié M, Salomon L
Service d'urologie, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Prog Urol. 2009 Dec;19(11):803-9. doi: 10.1016/j.purol.2009.04.010. Epub 2009 Jun 4.
To report the characteristics of prostate cancer (PCa) in men less than 50-year-old and the results of different treatments of PCa in this population.
A bibliographic research was performed using Pubmed database. The keywords that we used were: prostate cancer, age, young, radical prostatectomy, brachytherapy, radiotherapy, active surveillance. The studies which included a significant number of patients were selected. A total of 38 articles were used as bibliographic references.
PCa in young men does not seem to have different characteristics than in older men. Nevertheless, young men seem to have a lower risk of severe urinary and sexual sequelae, particularly following radical prostatectomy.
There is no recommendation regarding management of PCa in men less than 50-year-old. In case of localized cancer, two options may be considered. First option consists in decreasing the urinary and sexual complications of radical prostatectomy. A minimally-invasive treatment, such as brachytherapy or even active surveillance, may reach this objective. Second option consists in being more aggressive. To propose a radical prostatectomy offers to the patient the possibility of salvage radiation therapy in case of locally-advanced tumor or local recurrence.
报告50岁以下男性前列腺癌（PCa）的特征以及该人群中PCa不同治疗方法的结果。
使用PubMed数据库进行文献研究。我们使用的关键词为：前列腺癌、年龄、年轻、根治性前列腺切除术、近距离放射治疗、放射治疗、主动监测。选取纳入大量患者的研究。共38篇文章用作文献参考。
年轻男性的PCa似乎与老年男性没有不同特征。然而，年轻男性出现严重泌尿和性后遗症的风险似乎较低，尤其是在根治性前列腺切除术后。
对于50岁以下男性PCa的管理尚无推荐意见。对于局限性癌症，可考虑两种选择。第一种选择是减少根治性前列腺切除术的泌尿和性并发症。微创治疗，如近距离放射治疗甚至主动监测，可能达到这一目标。第二种选择是更积极一些。对于局部进展性肿瘤或局部复发的情况，提议进行根治性前列腺切除术可为患者提供挽救性放射治疗的可能性。
