Majewsky Vera, Arlt Sebastian, Shah Devika, Scherr Claudia, Jäger Tim, Betti Lucietta, Trebbi Grazia, Bonamin Leoni, Klocke Peter, Baumgartner Stephan
Research Institute of Organic Agriculture FiBL, Frick, Switzerland.
Homeopathy. 2009 Oct;98(4):228-43. doi: 10.1016/j.homp.2009.09.012.
The last comprehensive review of experimental research on effects of homeopathic treatments on plants was published in 1984, and lacked formal predefined criteria to assess study quality. Since then several new studies with more advanced methods have been published.
To compile a review of the literature on basic research in homeopathy with healthy plants with particular reference to studies investigating specific effects of homeopathic remedies.
The literature search included English, French, German, Italian, Portuguese and Spanish publications from 1920 to April 2009, using predefined selection criteria. We included experiments with healthy whole plants, seeds, plant parts and cells. The outcomes had to be measured by established procedures and statistically evaluated. We developed a Manuscript Information Score (MIS) and included only publications which provided enough information for proper interpretation (MIS>or=5). A formalised Study Methods Evaluation Procedure (SMEP) was used to evaluate these studies, and the subgroup of studies with adequate controls to identify specific effects.
A total of 86 studies in 79 publications was identified, 43 studies included statistics, 29 had MIS>or=5, and 15 studies investigated the specificity of homeopathic preparations. Specific effects of decimal, centesimal and fifty millesimal potencies were found including dilution levels far beyond the Avogadro number. In consecutive series of potencies only some of the tested potencies showed effects. There were many individual studies with diverse methods and very few reproduction trials.
Healthy plant models seem an useful approach to investigate basic research questions about the specificity of homeopathic preparations. More investigations with more advanced methods are recommended, especially in the sectors of potentisation techniques, effective potency levels and conditions for reproducibility. Systematic negative control experiments should become a routine procedure to control the stability of the experimental systems.
关于顺势疗法对植物影响的实验研究的上一次全面综述发表于1984年，且缺乏评估研究质量的正式预定义标准。自那时起，已发表了几项采用更先进方法的新研究。
汇编有关健康植物顺势疗法基础研究的文献综述，特别参考调查顺势疗法药物特定效果的研究。
文献检索涵盖1920年至2009年4月的英文、法文、德文、意大利文、葡萄牙文和西班牙文出版物，采用预定义的选择标准。我们纳入了对健康整株植物、种子、植物部分和细胞的实验。结果必须通过既定程序进行测量并进行统计评估。我们制定了稿件信息评分（MIS），仅纳入提供足够信息以便正确解读的出版物（MIS≥5）。采用形式化的研究方法评估程序（SMEP）来评估这些研究，以及有充分对照以确定特定效果的研究亚组。
共识别出79篇出版物中的86项研究，43项研究包含统计分析，29项MIS≥5，15项研究调查了顺势疗法制剂的特异性。发现了十进位、百进位和五十千进位效力的特定效果，包括远远超过阿伏伽德罗数的稀释水平。在连续的效力系列中，仅部分测试效力显示出效果。有许多方法各异的个别研究，而复现试验极少。
健康植物模型似乎是研究顺势疗法制剂特异性基础研究问题的有用方法。建议采用更先进方法进行更多调查，特别是在增效技术、有效效力水平和可重复性条件等方面。系统性阴性对照实验应成为控制实验系统稳定性的常规程序。
