Klein Sabine D, Würtenberger Sandra, Wolf Ursula, Baumgartner Stephan, Tournier Alexander
1 Institute of Complementary Medicine, University of Bern , Bern, Switzerland .
2 Scientific & Regulatory Affairs, Hevert-Arzneimittel GmbH & Co. KG , Nussbaum, Germany .
J Altern Complement Med. 2018 May;24(5):409-421. doi: 10.1089/acm.2017.0249. Epub 2018 Jan 29.
The last systematic review of physicochemical research performed on homeopathic preparations was published in 2003. The aim of the study is to update and expand the current state of knowledge in the area of physicochemical properties of homeopathic preparations. In part 1 of the study, we aim to present an overview of the literature with respect to publication quality and methods used. In part 2, we aim to identify the most interesting experimental techniques. With this, we aim to be in a position to generate meaningful hypotheses regarding a possible mode of action of homeopathic preparations.
A two-step procedure was adopted: (1) an extensive literature search, followed by a bibliometric and quality analysis on the level of publications and (2) a thorough qualitative analysis of the individual physicochemical investigations found. In this publication, we report on step (1). We searched major scientific databases to find publications reporting physicochemical investigations of homeopathy from its origin to the end of 2015. Publications were assessed using a scoring scheme, the Manuscript Information Score (MIS). Information regarding country of origin of the research and experimental techniques used was extracted.
We identified 183 publications (compared to 44 in the last review), 122 of which had an MIS ≥5. The rate of publication in the field was ∼2 per year from the 1970s until 2000. Afterward, it increased to over 5.5 publications per year. The quality of publications was seen to increase sharply from 2000 onward, whereas before 2000, only 12 (13%) publications were rated as "high quality" (MIS ≥7.5); 44 (48%) publications were rated as "high quality" from 2000 onward. Countries with most publications were Germany (n = 42, 23%), France (n = 29, 16%), India (n = 27, 15%), and Italy (n = 26, 14%). Techniques most frequently used were electrical impedance (26%), analytical methods (20%), spectroscopy (20%), and nuclear magnetic resonance (19%).
Physicochemical research into homeopathic preparations is increasing both in terms of quantity and quality of the publications.
上次对顺势疗法制剂进行的物理化学研究系统评价发表于2003年。本研究的目的是更新和扩展顺势疗法制剂物理化学性质领域的现有知识状态。在研究的第1部分，我们旨在就发表质量和所用方法对文献进行综述。在第2部分，我们旨在确定最有趣的实验技术。以此，我们旨在能够就顺势疗法制剂可能的作用方式提出有意义的假设。
采用两步程序：（1）广泛的文献检索，随后对出版物层面进行文献计量和质量分析，以及（2）对所发现的个体物理化学研究进行全面的定性分析。在本出版物中，我们报告步骤（1）。我们检索了主要科学数据库，以查找从顺势疗法起源到2015年底报告顺势疗法物理化学研究的出版物。使用一种评分方案，即手稿信息评分（MIS）对出版物进行评估。提取了有关研究起源国和所用实验技术的信息。
我们识别出183篇出版物（上次综述为44篇），其中122篇MIS≥5。从20世纪70年代到2000年，该领域的年发表率约为2篇。此后，年发表率增至每年超过5.5篇。从2000年起，出版物质量大幅提高，而在2000年之前，只有12篇（13%）出版物被评为“高质量”（MIS≥7.5）；从2000年起，44篇（48%）出版物被评为“高质量”。发表文章最多的国家是德国（n = 42，23%）、法国（n = 29，16%）、印度（n = 27，15%）和意大利（n = 26，14%）。最常用的技术是电阻抗（26%）、分析方法（20%）、光谱学（20%）和核磁共振（19%）。
顺势疗法制剂的物理化学研究在出版物的数量和质量方面都在增加。
