[分子生物学及曲霉半乳甘露聚糖抗原检测在组织胞浆菌病诊断中的作用]
[Contribution of molecular biology and Aspergillus galactomannan antigen assay for the diagnosis of histoplasmosis].
作者信息
Pineau S, Talarmin J-P, Morio F, Grossi O, Boutoille D, Léauté F, Le Pape P, Gay-Andrieu F, Miegeville M, Raffi F
机构信息
Service des Maladies Infectieuses et Tropicales, CHU Hôtel-Dieu, 1 place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
出版信息
Med Mal Infect. 2010 Sep;40(9):541-3. doi: 10.1016/j.medmal.2009.10.005. Epub 2009 Nov 28.
We report a case of a pulmonary histoplasmosis in an HIV-positive patient usually living in Cambodia, with a positive Aspergillus galactomannan antigenemia resulting from a cross-reaction, that decreased after antifungal therapy. We discuss the potential interest of the detection of fungal DNA by PCR and Aspergillus galactomannan antigenemia for the diagnosis of histoplasmosis, especially in countries where Histoplasma capsulatum antigen testing is not available.
我们报告一例通常居住在柬埔寨的HIV阳性患者发生肺组织胞浆菌病的病例，该患者因交叉反应导致半乳甘露聚糖抗原血症呈阳性，抗真菌治疗后该指标下降。我们讨论了通过PCR检测真菌DNA和半乳甘露聚糖抗原血症在组织胞浆菌病诊断中的潜在意义，特别是在无法进行荚膜组织胞浆菌抗原检测的国家。
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