由侵袭性头状地霉引起的曲霉半乳甘露聚糖酶联免疫吸附测定交叉反应性。
Aspergillus galactomannan enzyme-linked immunosorbent assay cross-reactivity caused by invasive Geotrichum capitatum.
作者信息
Giacchino Mareva, Chiapello Nadia, Bezzio Stefania, Fagioli Franca, Saracco Paola, Alfarano Alda, Martini Vincenza, Cimino Giuseppe, Martino Pietro, Girmenia Corrado
机构信息
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza of Rome, Via Benevento 6, 00161 Rome, Italy.
出版信息
J Clin Microbiol. 2006 Sep;44(9):3432-4. doi: 10.1128/JCM.00856-06.
Abstract
We report three cases of invasive Geotrichum capitatum infection in patients with acute leukemia for which an enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Supernatants obtained from suspensions of 17 G. capitatum strains gave positive reactions with the Aspergillus galactomannan ELISA. These clinical and laboratory data seem to suggest that G. capitatum produces a soluble antigen that is cross-reactive with Aspergillus galactomannan.
摘要
我们报告了3例急性白血病患者发生头状地霉侵袭性感染的病例，这些患者的曲霉半乳甘露聚糖酶联免疫吸附测定（ELISA）呈阳性，但无曲霉病证据。从17株头状地霉菌株的悬液中获得的上清液，与曲霉半乳甘露聚糖ELISA呈阳性反应。这些临床和实验室数据似乎表明，头状地霉产生了一种与曲霉半乳甘露聚糖有交叉反应的可溶性抗原。
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