基于腙-芘衍生物的选择性“开-关”荧光传感器用于检测细胞内 Zn(2+)及其应用。
A selective 'Off-On' fluorescent sensor for Zn(2+) based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn(2+).
机构信息
Department of Chemistry and Nano Science Ewha Womans University, Seoul 120-750, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2010 Jan 1;20(1):125-8. doi: 10.1016/j.bmcl.2009.11.028. Epub 2009 Nov 13.
PMID:19945868
Abstract
A simple and effective fluorescent sensor based on hydrazone-pyrene has been synthesized. This probe displays a highly selective fluorescent enhancement with Zn(2+), and application of this probe to detect the intrinsic Zn(2+) ions present in pancreatic beta-cells was successfully demonstrated.
摘要
合成了一种基于腙-芘的简单有效的荧光传感器。该探针对 Zn(2+)具有高度选择性的荧光增强作用，并成功应用于检测胰腺β细胞中存在的内源性 Zn(2+)离子。
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