Inserm, U837, Team 5 Mucins, epithelial differentiation and carcinogenesis Centre de Recherche Jean-Pierre Aubert, Place de Verdun, Lille Cedex, France.
J Clin Pathol. 2009 Dec;62(12):1144-6. doi: 10.1136/jcp.2008.060780.
To study the expression of MUC1 and MUC4 mucins in Barrett-associated oesophageal adenocarcinoma and coexisting lesions of the carcinogenic sequence (normal mucosa, metaplasia, dysplasia) if present, and to investigate their prognostic significance.
The expression profiles of MUC1 and MUC4 were investigated by immunohistochemistry in tissue samples obtained from consecutive patients with primary surgically resected lower third oesophageal adenocarcinoma (OA) between 1997 and 2002. Histopathological parameters, recurrence and long-term survival were correlated with the number of cells stained.
All 52 patients exhibited OA, with 25 patients (48.1%) having associated Barrett oesophagus lesions (metaplasia or/and dysplasia). MUC1 and MUC4 were expressed in 52 and 41 of the 52 patients with adenocarcinoma (100% and 78%), respectively. All samples expressed MUC1 strongly. The prevalence of MUC4 staining was significantly decreased in metaplasia compared with normal mucosa (53% versus 92%, p<0.001). No correlation was found between the level of MUC1 or MUC4 expression in OA and histopathological variables, recurrence or survival.
MUC1 and MUC4 are strongly expressed in OA. The results do not support a role for these two membrane-bound mucins as either a phenotypic or a prognostic marker for the development of Barrett OA. There are several other membrane-bound mucins that have not yet been evaluated in this situation.
研究 MUC1 和 MUC4 黏蛋白在 Barrett 相关食管腺癌（OA）及致癌序列中并存病变（正常黏膜、化生、异型增生）中的表达情况，如果存在的话，并探讨其预后意义。
本研究采用免疫组织化学方法检测了 1997 年至 2002 年间连续接受手术切除的下段食管原发性 OA 患者的组织样本中 MUC1 和 MUC4 的表达谱。将组织病理学参数、复发和长期生存与染色细胞数量相关联。
所有 52 例患者均表现为 OA，其中 25 例（48.1%）伴有 Barrett 食管病变（化生或/和异型增生）。52 例腺癌患者中有 52 例（100%）和 41 例（78%）表达 MUC1 和 MUC4。所有样本均强烈表达 MUC1。MUC4 染色在化生中的阳性率明显低于正常黏膜（53%对 92%，p<0.001）。OA 中 MUC1 或 MUC4 的表达水平与组织病理学变量、复发或生存无相关性。
MUC1 和 MUC4 在 OA 中强烈表达。结果不支持这两种膜结合黏蛋白作为 Barrett OA 发展的表型或预后标志物的作用。在这种情况下，还有其他几种膜结合黏蛋白尚未进行评估。
