Sun Zhi-Gang, Yu Li, Gao Wei, Wang Zhou, Zhu Liang-Ming
Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China.
Department of Otorhinolaryngology, Jinan Central Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, China.
Saudi J Gastroenterol. 2018 May-Jun;24(3):165-170. doi: 10.4103/sjg.SJG_420_17.
BACKGROUND/AIM: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection.
A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect MUC1 at the mRNA level and were evaluated by immunohistochemistry (IHC) to detect MUC1 at the protein level.
MUC1 mRNA was found in 74 cases by RT-PCR and MUC1 protein expression was found by IHC in 70 cases. Both MUC1 mRNA and protein expression correlated with pT (<0.05), pN (P < 0.01), and pTNM (<0.01). The 5-year survival rates of the patients were 39.8%. In univariate analysis, the 5-year survival rate in the ESCC patients was significantly associated with pT (P < 0.01), pN (P < 0.01), pTNM stage (P < 0.01), and MUC1 mRNA and protein expression (P < 0.05). In multivariate analysis, pN and MUC1 expression were the independent relevant factors.
MUC1 expression can become a useful marker to predict poor prognostic factors for 5-year survival rate in patients with ESCC after radical resection.
背景/目的：探讨MUC1表达在食管鳞状细胞癌（ESCC）根治性切除术后患者中的临床及预后意义。
采用逆转录聚合酶链反应（RT-PCR）对108例ESCC标本进行评估，以检测mRNA水平的MUC1，并采用免疫组织化学（IHC）检测蛋白水平的MUC1。
RT-PCR检测发现74例存在MUC1 mRNA，IHC检测发现70例存在MUC1蛋白表达。MUC1 mRNA和蛋白表达均与pT（<0.05）、pN（P<0.01）和pTNM（<0.01）相关。患者的5年生存率为39.8%。单因素分析显示，ESCC患者的5年生存率与pT（P<0.01）、pN（P<0.01）、pTNM分期（P<0.01）以及MUC1 mRNA和蛋白表达（P<0.05）显著相关。多因素分析显示，pN和MUC1表达是独立的相关因素。
MUC1表达可成为预测ESCC根治性切除术后患者5年生存率不良预后因素的有用标志物。
