McCarthy James S, Good Michael F
Queensland Institute for Medical Research and School of Medicine, University of Queensland, Queensland, Australia.
Hum Vaccin. 2010 Jan;6(1):114-23. doi: 10.4161/hv.6.1.10394. Epub 2010 Jan 21.
There is a growing realization of the limitations of recombinant protein-based malaria vaccines. This, coupled with a better understanding of the protective immunity to malaria, both in animal models and in naturally exposed human populations and experimentally infected volunteers, as well as the increased capacity to manipulate parasites provides new impetus to evaluate whole blood stage parasite approaches to malaria vaccine development. In this review previous studies in rodents and primates of whole killed and attenuated blood stage vaccines, and recent work on the effect of genetically attenuated parasites on immunity in rodent models of blood stage immunity are discussed. The relationship between these findings and what is now known about protective immunity in human populations, specifically against the blood stages of the parasite lifecycle is discussed and recent findings from human experimental infection are be reviewed. Finally, the prospect for and impediments to the development whole blood stage parasites are reviewed.
人们越来越意识到基于重组蛋白的疟疾疫苗存在局限性。这一点，再加上对疟疾保护性免疫的更深入理解，无论是在动物模型、自然暴露的人群以及实验感染的志愿者中，以及操纵寄生虫能力的增强，都为评估全血期寄生虫方法用于疟疾疫苗开发提供了新的动力。在这篇综述中，讨论了以往在啮齿动物和灵长类动物中对全灭活和减毒血期疫苗的研究，以及近期关于基因减毒寄生虫对血期免疫啮齿动物模型中免疫影响的工作。讨论了这些发现与目前已知的人群保护性免疫之间的关系，特别是针对寄生虫生命周期血期的免疫，并综述了人体实验感染的最新发现。最后，综述了全血期寄生虫开发的前景和障碍。
