Rénia L
Laboratory of Malaria Immunobiology, Singapore Immunolog Network, Agency for Science, Technology and Research, Immunos, Singapore 138673, Singapore.
Parasite. 2008 Sep;15(3):379-83. doi: 10.1051/parasite/2008153379.
Despite nearly 100 years of research and control efforts, malaria remains one of the most important infectious diseases. An efficient vaccine would be a powerful to tool to reduce mortality and morbidity. Experimentally, induction of sterile immunity in humans after vaccination with attenuated sporozoites has been obtained. This observation has spurred the search for subunit vaccines that aim to reproduce this protection. As yet none of the current candidate subunit vaccines achieved complete protection reproducibly. This failure coupled to the recent advent of genetically modified Plasmodium parasites has led to a renewed interest in the use of live parasites for vaccination against malaria pre-erythrocytic stages. In this article, we review and discuss the recent developments in this field.
尽管经过了近百年的研究和防控努力，疟疾仍然是最重要的传染病之一。一种有效的疫苗将是降低死亡率和发病率的有力工具。在实验中，已通过接种减毒子孢子在人体中诱导出了无菌免疫力。这一观察结果促使人们寻找旨在重现这种保护作用的亚单位疫苗。然而，目前的候选亚单位疫苗均未能够可靠地实现完全保护。这种失败再加上最近转基因疟原虫的出现，使得人们对使用活寄生虫进行疟疾红细胞前期阶段疫苗接种重新产生了兴趣。在本文中，我们回顾并讨论了该领域的最新进展。
