益生菌在过敏性疾病中的作用。
The role of probiotics in allergic diseases.
机构信息
Department of Gastroenterology and Nutrition, Wright State University Boonshoft School of Medicine Dayton Children's Medical Center, Dayton, Ohio 45404, USA.
出版信息
Allergy Asthma Clin Immunol. 2009 Oct 22;5(1):5. doi: 10.1186/1710-1492-5-5.
Abstract
Allergic disorders are very common in the pediatric age group. While the exact etiology is unclear, evidence is mounting to incriminate environmental factors and an aberrant gut microbiota with a shift of the Th1/Th2 balance towards a Th2 response. Probiotics have been shown to modulate the immune system back to a Th1 response. Several in vitro studies suggest a role for probiotics in treating allergic disorders. Human trials demonstrate a limited benefit for the use of probiotics in atopic dermatitis in a preventive as well as a therapeutic capacity. Data supporting their use in allergic rhinitis are less robust. Currently, there is no role for probiotic therapy in the treatment of bronchial asthma. Future studies will be critical in determining the exact role of probiotics in allergic disorders.
摘要
过敏症在儿科中非常常见。虽然确切的病因尚不清楚，但越来越多的证据表明环境因素和肠道菌群异常与 Th1/Th2 平衡向 Th2 反应转移有关。益生菌已被证明可以使免疫系统恢复到 Th1 反应。几项体外研究表明益生菌在治疗过敏症方面具有一定作用。人体试验表明，益生菌在预防和治疗特应性皮炎方面具有一定的益处。支持其在过敏性鼻炎中应用的数据则不那么有力。目前，益生菌疗法在治疗支气管哮喘方面没有作用。未来的研究对于确定益生菌在过敏症中的确切作用至关重要。
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本文引用的文献
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Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials.益生菌治疗小儿特应性皮炎的疗效：随机对照试验的荟萃分析。
Ann Allergy Asthma Immunol. 2008 Nov;101(5):508-16. doi: 10.1016/S1081-1206(10)60290-6.
2
Children living in areas with more street trees have lower prevalence of asthma.生活在街道树木较多地区的儿童哮喘患病率较低。
J Epidemiol Community Health. 2008 Jul;62(7):647-9. doi: 10.1136/jech.2007.071894. Epub 2008 May 1.
3
Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis.益生菌预防和治疗小儿特应性皮炎临床试验的荟萃分析。
J Allergy Clin Immunol. 2008 Jan;121(1):116-121.e11. doi: 10.1016/j.jaci.2007.10.043.
4
Probiotics in infants for prevention of allergic disease and food hypersensitivity.婴儿使用益生菌预防过敏性疾病和食物过敏
Cochrane Database Syst Rev. 2007 Oct 17(4):CD006475. doi: 10.1002/14651858.CD006475.pub2.
5
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Allergy. 2007 Nov;62(11):1270-6. doi: 10.1111/j.1398-9995.2007.01543.x.
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