Aggarwal Sunil K, Carter Gregory T, Sullivan Mark D, ZumBrunnen Craig, Morrill Richard, Mayer Jonathan D
University of Washington, Seattle, Washington, USA.
J Opioid Manag. 2009 Sep-Oct;5(5):257-86. doi: 10.5055/jom.2009.0028.
This study was conducted to better understand the characteristics of chronic pain patients seeking treatment with medicinal cannabis (MC).
Retrospective chart reviews of 139 patients (87 males, median age 47 years; 52 females, median age 48 years); all were legally qualified for MC use in Washington State.
Regional pain clinic staffed by university faculty.
age 18 years and older; having legally accessed MC treatment, with valid documentation in their medical records. All data were de-identified.
Records were scored for multiple indicators, including time since initial MC authorization, qualifying condition(s), McGill Pain score, functional status, use of other analgesic modalities, including opioids, and patterns of use over time.
Of 139 patients, 15 (11 percent) had prior authorizations for MC before seeking care in this clinic. The sample contained 236.4 patient-years of authorized MC use. Time of authorized use ranged from 11 days to 8.31 years (median of 1.12 years). Most patients were male (63 percent) yet female patients averaged 0.18 years longer authorized use. There were no other gender-specific trends or factors. Most patients (n = 123, 88 percent) had more than one pain syndrome present. Myofascial pain syndrome was the most common diagnosis (n = 114, 82 percent), followed by neuropathic pain (n = 89, 64 percent), discogenic back pain (n = 72, 51.7 percent), and osteoarthritis (n = 37, 26.6 percent). Other diagnoses included diabetic neuropathy, central pain syndrome, phantom pain, spinal cord injury, fibromyalgia, rheumatoid arthritis, HIV neuropathy, visceral pain, and malignant pain. In 51 (37 percent) patients, there were documented instances of major hurdles related to accessing MC, including prior physicians unwilling to authorize use, legal problems related to MC use, and difficulties in finding an affordable and consistent supply of MC.
Data indicate that males and females access MC at approximately the same rate, with similar median authorization times. Although the majority of patient records documented significant symptom alleviation with MC, major treatment access and delivery barriers remain.
开展本研究以更好地了解寻求药用大麻(MC)治疗的慢性疼痛患者的特征。
对139例患者(87例男性,中位年龄47岁;52例女性,中位年龄48岁)进行回顾性病历审查;所有患者在华盛顿州均具备合法使用MC的资格。
由大学教员配备人员的区域疼痛诊所。
年龄18岁及以上;已合法接受MC治疗,病历中有有效记录。所有数据均经过去识别处理。
对病历进行多项指标评分,包括自首次获得MC授权以来的时间、符合条件的病症、麦吉尔疼痛评分、功能状态、其他镇痛方式(包括阿片类药物)的使用情况以及随时间的使用模式。
139例患者中,15例(11%)在本诊所就诊前曾获得MC的预先授权。该样本包含236.4患者年的MC授权使用时间。授权使用时间从11天到8.31年不等(中位时间为1.12年)。大多数患者为男性(63%),但女性患者的平均授权使用时间长0.18年。没有其他性别特异性趋势或因素。大多数患者(n = 123,88%)存在一种以上疼痛综合征。肌筋膜疼痛综合征是最常见的诊断(n = 114,82%),其次是神经性疼痛(n = 89,64%)、椎间盘源性背痛(n = 72,51.7%)和骨关节炎(n = 37,26.6%)。其他诊断包括糖尿病性神经病变、中枢性疼痛综合征、幻肢痛、脊髓损伤、纤维肌痛、类风湿关节炎、HIV神经病变、内脏痛和恶性疼痛。在51例(37%)患者中,有记录表明在获取MC方面存在重大障碍,包括之前的医生不愿意授权使用、与MC使用相关的法律问题以及难以找到价格合理且稳定的MC供应。
数据表明,男性和女性获取MC的比例大致相同,中位授权时间相似。尽管大多数患者记录显示MC能显著缓解症状,但在治疗获取和供应方面仍存在重大障碍。