Düzce Medical School Department of Cardiology, Duzce University, 81620 Konuralp, Düzce, Turkey.
Platelets. 2010;21(1):29-32. doi: 10.3109/09537100903391023.
Mean platelet volume (MPV) is an indicator of platelet activation. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease. Non-alcoholic fatty liver disease (NAFLD) is present up to one-third of the general population and the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type 2 diabetes and other components of the metabolic syndrome (MS). The aim of the current study was to investigate the MPV in patients who had NAFLD. MPV values of the patients with NAFLD and of the patients without fatty liver disease were compared. NAFLD patients had significantly higher body mass index compared to the control cases. Among biochemical variables, fasting plasma glucose and triglyceride were significantly higher in the NAFLD group. NAFLD cases also had lower platelet count and higher MPV (10.43 +/- 1.14 vs. 9.09 +/- 1.25; p < 0.001, respectively). MPV was positively correlated with AST (r: 0.186, p < 0.042), ALT level (r: 0.279; p 0.002) and the presence of NAFLD (0.492; p < 0.001) but negatively correlated with platelet number (r: -0.26; p 0.004) and creatinine (r: -0.255; p 0.005). In logistic regression analysis (age, gender, NAFLD, body mass index, high-density lipid (HDL) cholesterol, systolic and diastolic blood pressure, triglyceride and fasting plasma glucose were used as covariates) only NAFLD was found to be the independent predictor of MPV (Odds Ratio (OR) 21.98) [95% confidence interval (CI): 2.404-201.048; p: 0.006]. We have shown for the first time in the literature that, patients with NAFLD have higher MPV. It may have prognostic value in NAFLD patients indicating a possible cardiovascular disease (CVD) risk increase.
平均血小板体积 (MPV) 是血小板活化的指标。血小板活化和聚集是冠心病病理生理学的核心过程。非酒精性脂肪性肝病 (NAFLD) 可在三分之一的普通人群中出现，并且大多数患有代谢危险因素的患者，如腹部肥胖、2 型糖尿病和代谢综合征 (MS) 的其他组成部分。本研究旨在探讨患有 NAFLD 的患者的 MPV 值。比较了 NAFLD 患者和无脂肪肝疾病患者的 MPV 值。与对照组相比，NAFLD 患者的体重指数明显更高。在生化变量中，空腹血糖和甘油三酯在 NAFLD 组中明显升高。NAFLD 患者的血小板计数也较低，MPV 较高（10.43 +/- 1.14 对 9.09 +/- 1.25；分别为 p < 0.001）。MPV 与 AST（r：0.186，p < 0.042）、ALT 水平（r：0.279；p < 0.002）和 NAFLD 的存在呈正相关（r：0.492；p < 0.001），但与血小板计数呈负相关（r：-0.26；p < 0.004）和肌酐（r：-0.255；p < 0.005）。在逻辑回归分析中（年龄、性别、NAFLD、体重指数、高密度脂蛋白 (HDL) 胆固醇、收缩压和舒张压、甘油三酯和空腹血糖作为协变量），只有 NAFLD 被发现是 MPV 的独立预测因子（优势比（OR）21.98）[95%置信区间（CI）：2.404-201.048；p：0.006]。我们首次在文献中表明，患有 NAFLD 的患者 MPV 较高。它可能在 NAFLD 患者中具有预后价值，表明可能增加心血管疾病 (CVD) 风险。
