Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.
Mol Pain. 2009 Nov 30;5:69. doi: 10.1186/1744-8069-5-69.
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence for this mechanism in urinary bladder, ureter, gut, lung, uterus, tooth-pulp and tongue is reviewed. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by agents that interfere with mechanosensory transduction in the organs considered, including P2X3 and P2X2/3 receptor antagonists that are orally bioavailable and stable in vivo and agents that inhibit or enhance ATP release and breakdown.
在这篇综述中，提出了证据支持机械感觉转导发生在管和囊中，并能引发内脏疼痛的假说。本文综述了机械感觉转导在膀胱、输尿管、肠道、肺、子宫、牙髓和舌等器官中的实验证据。考虑了通过干扰所考虑的器官中的机械感觉转导的药物，如 P2X3 和 P2X2/3 受体拮抗剂，这些药物具有口服生物利用度和体内稳定性，以及抑制或增强 ATP 释放和分解的药物，来治疗肾绞痛、间质性膀胱炎和炎症性肠病等疾病中的内脏疼痛的潜在治疗策略。
