• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

嘌呤能机制与疼痛——最新进展。

Purinergic mechanisms and pain--an update.

机构信息

Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom.

出版信息

Eur J Pharmacol. 2013 Sep 15;716(1-3):24-40. doi: 10.1016/j.ejphar.2013.01.078. Epub 2013 Mar 22.

DOI:10.1016/j.ejphar.2013.01.078
PMID:23524093
Abstract

There is a brief summary of the background literature about purinergic signalling. The review then considers purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the roles played by P2X3, P2X2/3, P2X4, P2X7 and P2Y₁₂ receptors in neuropathic and inflammatory pain. Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed.

摘要

简要概述了关于嘌呤能信号的背景文献。然后，本文综述了内脏、皮肤和肌肉骨骼痛觉中的嘌呤能机械感觉转导，以及 P2X3、P2X2/3、P2X4、P2X7 和 P2Y12 受体在神经病理性和炎性疼痛中的作用。本文还讨论了用于治疗内脏痛和神经病理性疼痛的化合物的最新进展。

相似文献

1
Purinergic mechanisms and pain--an update.嘌呤能机制与疼痛——最新进展。
Eur J Pharmacol. 2013 Sep 15;716(1-3):24-40. doi: 10.1016/j.ejphar.2013.01.078. Epub 2013 Mar 22.
2
Purinergic Mechanisms and Pain.嘌呤能机制与疼痛
Adv Pharmacol. 2016;75:91-137. doi: 10.1016/bs.apha.2015.09.001. Epub 2015 Nov 4.
3
Purinergic receptors and pain.嘌呤能受体与疼痛。
Curr Pharm Des. 2009;15(15):1717-35. doi: 10.2174/138161209788186335.
4
Purinergic P2 receptors as targets for novel analgesics.嘌呤能P2受体作为新型镇痛药的靶点。
Pharmacol Ther. 2006 Jun;110(3):433-54. doi: 10.1016/j.pharmthera.2005.08.013. Epub 2005 Oct 13.
5
Purinergic systems, neuropathic pain and the role of microglia.嘌呤能系统、神经病理性疼痛和小胶质细胞的作用。
Exp Neurol. 2012 Apr;234(2):293-301. doi: 10.1016/j.expneurol.2011.09.016. Epub 2011 Sep 17.
6
Purines and pain mechanisms: recent developments.嘌呤与疼痛机制：最新进展
Curr Opin Investig Drugs. 2005 Jan;6(1):65-75.
7
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.内源性阿片机制部分介导了炎症性疼痛和化学性疼痛大鼠模型中与P2X3/P2X2/3相关的抗伤害感受，但在神经性疼痛中并非如此。
Br J Pharmacol. 2005 Sep;146(2):180-8. doi: 10.1038/sj.bjp.0706346.
8
Purinergic mechanosensory transduction and visceral pain.嘌呤能机械感觉转导与内脏痛。
Mol Pain. 2009 Nov 30;5:69. doi: 10.1186/1744-8069-5-69.
9
Purines and sensory nerves.嘌呤与感觉神经。
Handb Exp Pharmacol. 2009(194):333-92. doi: 10.1007/978-3-540-79090-7_10.
10
Purinergic Signaling in Endometriosis-Associated Pain.嘌呤能信号在子宫内膜异位症相关疼痛中的作用。
Int J Mol Sci. 2020 Nov 12;21(22):8512. doi: 10.3390/ijms21228512.

引用本文的文献

1
Emerging treatments for chronic neuropathic pain from a cross-disease perspective: developments and applications of nanomaterials.从跨疾病角度看慢性神经性疼痛的新兴治疗方法：纳米材料的发展与应用
J Headache Pain. 2025 Jun 17;26(1):143. doi: 10.1186/s10194-025-02081-5.
2
Safety, Tolerability, and Pharmacokinetics of Filapixant, a Highly Selective P2X3 Receptor Antagonist, in an Ascending-Single-Dose First-in-Human Study.在一项单剂量递增的首次人体研究中，高选择性P2X3受体拮抗剂非拉匹生的安全性、耐受性和药代动力学
Pharmaceuticals (Basel). 2025 May 20;18(5):758. doi: 10.3390/ph18050758.
3
The Role of Purinergic Mechanisms in the Excitability of Trigeminal Afferents of Rats with Prenatal Hyperhomocysteinemia.
嘌呤能机制在产前高同型半胱氨酸血症大鼠三叉神经传入纤维兴奋性中的作用
Biomolecules. 2025 Mar 15;15(3):419. doi: 10.3390/biom15030419.
4
Molecular Anatomy of Synaptic and Extrasynaptic Neurotransmission Between Nociceptive Primary Afferents and Spinal Dorsal Horn Neurons.伤害性初级传入神经元与脊髓背角神经元之间突触性和突触外神经传递的分子解剖学
Int J Mol Sci. 2025 Mar 6;26(5):2356. doi: 10.3390/ijms26052356.
5
Electroacupuncture alleviates neuropathic pain in a rat model of CCD via suppressing P2X3 expression in dorsal root ganglia.电针通过抑制背根神经节中P2X3的表达减轻慢性压迫性损伤大鼠模型的神经性疼痛。
Chin Med. 2024 Nov 11;19(1):156. doi: 10.1186/s13020-024-01030-9.
6
Interstitial Cells of Cajal and PX Receptors at Ureteropelvic Junction Obstruction and Their Relationship with Pain Response.输尿管肾盂连接处梗阻时的Cajal间质细胞和PX受体及其与疼痛反应的关系。
J Clin Med. 2024 Apr 4;13(7):2109. doi: 10.3390/jcm13072109.
7
Effects of Nitric Oxide on the Activity of P2X and TRPV1 Receptors in Rat Meningeal Afferents of the Trigeminal Nerve.一氧化氮对大鼠三叉神经脑膜传入纤维 P2X 和 TRPV1 受体活性的影响。
Int J Mol Sci. 2023 Apr 19;24(8):7519. doi: 10.3390/ijms24087519.
8
Purinergic signaling: Diverse effects and therapeutic potential in cancer.嘌呤能信号传导：在癌症中的多种作用及治疗潜力
Front Oncol. 2023 Jan 18;13:1058371. doi: 10.3389/fonc.2023.1058371. eCollection 2023.
9
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects.靶向离子通道的双膦酸盐与肌肉骨骼效应
Front Pharmacol. 2022 Mar 15;13:837534. doi: 10.3389/fphar.2022.837534. eCollection 2022.
10
The Role of Microglial Purinergic Receptors in Pain Signaling.小胶质细胞嘌呤能受体在痛觉信号转导中的作用。
Molecules. 2022 Mar 16;27(6):1919. doi: 10.3390/molecules27061919.