Vision Sciences, Glasgow Caledonian University, Glasgow, UK.
Ocul Surf. 2009 Oct;7(4):186-98. doi: 10.1016/s1542-0124(12)70186-6.
Meta-analyses were carried out of studies of tear production (by fluorophotometry, tear turnover rate[TTR]) and evaporation (from capture of fluid loss from the eye). TTR was reduced in dry eye relative to normal at 9.26 +/- 5.08%/min (0.54 +/- 0.28 μl/min) vs 16.19 +/- 5.1%/min (1.03 +/- 0.39 μl/min); with values of 7.71 +/- 1.02 %/min (0.4 +/- 0.10 μl/min) in aqueous deficiency dry eye (ADDE) and 11.95 +/- 4.25%/min (0.71 +/- 0.25 l/min) in evaporative dry eye (EDE). Evaporation was increased in dry eye at 21.05 +/- 13.96 x 10(-7)g/cm(2)/s (0.21 +/- 0.13 μl/min) vs 13.57 +/- 6.52 x 10(-7)g/cm(2)/s (0.14 +/- 0.07 μl/min) in normals; with values of 17.91 +/- 10.49 x 10(-7)g/cm(2)/s (0.17 +/- 0.1 μl/min) in ADDE and 25.34 +/- 13.08 x 10(-7)g/cm(2)/s (0.26 +/- 0.16 μl/min) in EDE. Evaporation rate from tear film thinning was also considered, and possible reasons and consequences for the much higher rates thereby reported are discussed. A new statistical approach determined diagnostic efficacy of cut-offs for dry eye derived from the meta-analyses; sensitivities and specifications ranging from 69.5 to 98.6% and 58.7 to 96.8% (TTR) and 45.5 to 61.2% and 79.8 to 90.6% (evaporation). Indices of tear dynamics were reconsidered, and ratios of evaporation and TTR suggest that an increase of between 2 and 3 times may be associated with dry eye.
进行了泪液生成（荧光光度法，泪液周转率[TTR]）和蒸发（从眼睛中损失的液体捕捉）的研究的荟萃分析。与正常相比，干眼症的 TTR 降低，相对值为 9.26 +/- 5.08%/min（0.54 +/- 0.28 μl/min）比 16.19 +/- 5.1%/min（1.03 +/- 0.39 μl/min）；在水性缺乏性干眼症（ADDE）中为 7.71 +/- 1.02 %/min（0.4 +/- 0.10 μl/min），在蒸发性干眼症（EDE）中为 11.95 +/- 4.25%/min（0.71 +/- 0.25 l/min）。干眼症的蒸发率增加，相对值为 21.05 +/- 13.96 x 10(-7)g/cm(2)/s（0.21 +/- 0.13 μl/min）比正常的 13.57 +/- 6.52 x 10(-7)g/cm(2)/s（0.14 +/- 0.07 μl/min）；在 ADDE 中为 17.91 +/- 10.49 x 10(-7)g/cm(2)/s（0.17 +/- 0.1 μl/min），在 EDE 中为 25.34 +/- 13.08 x 10(-7)g/cm(2)/s（0.26 +/- 0.16 μl/min）。还考虑了从泪膜变薄的蒸发率，讨论了报告的高得多的蒸发率的可能原因和后果。一种新的统计方法确定了从荟萃分析中得出的干眼症诊断截止值的诊断效果；灵敏度和特异性范围为 69.5%至 98.6%和 58.7%至 96.8%（TTR）和 45.5%至 61.2%和 79.8%至 90.6%（蒸发）。重新考虑了泪液动力学指数，蒸发率和 TTR 的比值表明，增加 2 到 3 倍可能与干眼症有关。
