Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Curr Biol. 2009 Dec 1;19(22):R1036-8. doi: 10.1016/j.cub.2009.10.032.
The small GTP-binding protein Arf6 is known to be an important regulator of the actin cytoskeleton and of cell motility associated with metastasis. A recent study identifies yet another role for Arf6 in metastasis - as a regulator of plasma-membrane-derived microvesicle release.
小分子 GTP 结合蛋白 Arf6 是众所周知的肌动蛋白细胞骨架和与转移相关的细胞运动的重要调节因子。最近的一项研究确定了 Arf6 在转移中的另一个作用 - 作为质膜衍生的微泡释放的调节剂。