Li Rui, Peng Cheng, Zhang Xianzhe, Wu Yuewei, Pan Shida, Xiao Yechen
Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiology, School of Public Health, Jilin University, Changchun, China.
Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China.
Life Sci. 2017 Aug 1;182:80-84. doi: 10.1016/j.lfs.2017.06.008. Epub 2017 Jun 15.
ADP-ribosylation factor 6 (Arf6), a member of small GTPases ADP-ribosylation factor (Arf) family, expresses widely in mammalian cells and mainly regulates the functions of membrane traffic and actin remodeling. Current studies indicated that the activation and high expression of Arf6 protein may be significantly correlated with the invasion and metastasis of several tumors, such as breast cancer, pancreatic cancer, lung cancer, etc. Meanwhile, the ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6. To explore the precisely potential mechanisms between Arf6 and the process of tumor invasion, metastasis and proliferation, we concludes the functions and potential signaling pathways of Arf6 in tumor cells and provides an overview about clinical prospects of Arf6 in the screening, diagnosis, treatment and evaluation of prognosis of neoplasms.
ADP核糖基化因子6（Arf6）是小GTP酶ADP核糖基化因子（Arf）家族的成员之一，在哺乳动物细胞中广泛表达，主要调节膜运输和肌动蛋白重塑功能。目前的研究表明，Arf6蛋白的激活和高表达可能与几种肿瘤（如乳腺癌、胰腺癌、肺癌等）的侵袭和转移显著相关。同时，当Arf6的活性被Arf6抑制剂或小干扰RNA阻断时，肿瘤侵袭和转移能力可受到抑制。为了探究Arf6与肿瘤侵袭、转移和增殖过程之间确切的潜在机制，我们总结了Arf6在肿瘤细胞中的功能和潜在信号通路，并概述了Arf6在肿瘤筛查、诊断、治疗及预后评估方面的临床前景。
