ARF6 介导向内体再循环影响细胞运动、细胞分裂和脂质动态平衡。
ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.
机构信息
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556-0369, USA.
出版信息
Semin Cell Dev Biol. 2011 Feb;22(1):39-47. doi: 10.1016/j.semcdb.2010.09.002. Epub 2010 Sep 15.
Abstract
A wide range of cellular activities depends upon endocytic recycling. ARF6, a small molecular weight GTPase, regulates the processes of endocytosis and endocytic recycling in concert with various effector molecules and other small GTPases. This review highlights three critical processes that involve ARF6-mediated endosomal membrane trafficking-cell motility, cytokinesis, and cholesterol homeostasis. In each case, the function of ARF6-mediated trafficking varies-including localization of specific protein and lipid cargo, regulation of bulk membrane movement, and modulation of intracellular signaling. As described in this review, mis-regulation of endocytic traffic can result in human disease when it compromises the cell's ability to regulate cell movement and invasion, cell division, and lipid homeostasis.
摘要
广泛的细胞活动依赖于内吞作用的回收。ARF6，一种小分子 GTPase，与各种效应分子和其他小 GTPase 一起协调内吞作用和内吞作用的回收过程。这篇综述强调了涉及 ARF6 介导的内体膜运输的三个关键过程-细胞运动、胞质分裂和胆固醇稳态。在每种情况下，ARF6 介导的运输的功能都不同-包括特定蛋白质和脂质货物的定位、大块膜运动的调节以及细胞内信号的调节。正如本文综述所述，当内吞作用的运输受到影响，从而损害细胞调节细胞运动和侵袭、细胞分裂和脂质稳态的能力时，内吞作用的运输会导致人类疾病。
相似文献
1
ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.ARF6 介导向内体再循环影响细胞运动、细胞分裂和脂质动态平衡。
Semin Cell Dev Biol. 2011 Feb;22(1):39-47. doi: 10.1016/j.semcdb.2010.09.002. Epub 2010 Sep 15.
2
An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.一个 ARF6/Rab35 G 蛋白循环用于内吞体循环和成功的胞质分裂。
Curr Biol. 2012 Jan 24;22(2):147-53. doi: 10.1016/j.cub.2011.11.058. Epub 2012 Jan 5.
3
CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration.CD13 将 IQGAP1-ARF6-EFA6 复合物固定在质膜上，促进 ARF6 的激活、β1 整合素的回收和细胞迁移。
Sci Signal. 2019 Apr 30;12(579):eaav5938. doi: 10.1126/scisignal.aav5938.
4
Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes.Arf6 驱动的 CD147 内吞回收决定 HCC 恶性表型。
J Exp Clin Cancer Res. 2019 Nov 21;38(1):471. doi: 10.1186/s13046-019-1464-9.
5
Arl13b regulates endocytic recycling traffic.Arl13b 调控内吞回收运输。
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21354-9. doi: 10.1073/pnas.1218272110. Epub 2012 Dec 7.
6
Virus Control of Trafficking from Sorting Endosomes.病毒控制分拣内体中的运输。
mBio. 2018 Jul 24;9(4):e00683-18. doi: 10.1128/mBio.00683-18.
7
The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.衔接蛋白复合物AP-2通过非网格蛋白依赖的Arf6内吞途径调节内吞后运输。
J Cell Sci. 2008 Dec 15;121(Pt 24):4008-17. doi: 10.1242/jcs.033522. Epub 2008 Nov 25.
8
Internalization of exogenous ADP-ribosylation factor 6 (Arf6) proteins into cells.细胞内的外源性 ADP-ribosylation factor 6（Arf6）蛋白的内化。
Mol Cell Biochem. 2011 Aug;354(1-2):291-9. doi: 10.1007/s11010-011-0829-y. Epub 2011 Apr 27.
9
Small GTPase ARF6 Regulates Endocytic Pathway Leading to Degradation of ATP-Binding Cassette Transporter A1.小GTP酶ARF6调节导致ATP结合盒转运体A1降解的内吞途径。
Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2292-2303. doi: 10.1161/ATVBAHA.116.308418. Epub 2016 Oct 6.
10
Arf6 regulates RhoB subcellular localization to control cancer cell invasion.Arf6 调节 RhoB 的亚细胞定位以控制癌细胞侵袭。
J Cell Biol. 2019 Nov 4;218(11):3812-3826. doi: 10.1083/jcb.201806111. Epub 2019 Oct 7.
引用本文的文献
1
Sequence Determinants of Allosteric Back-to-front Control of the Arf Nucleotide Switch.Arf核苷酸开关变构前后控制的序列决定因素
J Mol Biol. 2025 Jul 26;437(19):169361. doi: 10.1016/j.jmb.2025.169361.
2
Identification and validation of ARF6 for a potential prognostic biomarker of acute myeloid leukemia.急性髓系白血病潜在预后生物标志物ARF6的鉴定与验证
Cancer Cell Int. 2025 Jun 20;25(1):218. doi: 10.1186/s12935-025-03847-2.
3
Revisiting Pathogen Exploitation of Clathrin-Independent Endocytosis: Mechanisms and Implications.重新审视病原体对网格蛋白非依赖性内吞作用的利用：机制与影响
Cells. 2025 May 16;14(10):731. doi: 10.3390/cells14100731.
4
Redox response feature and mechanism of Arf1 and their implications for those of Ras and Rho GTPases.Arf1的氧化还原反应特征、机制及其对Ras和Rho GTP酶的影响。
J Biol Chem. 2025 Jun;301(6):110269. doi: 10.1016/j.jbc.2025.110269. Epub 2025 May 21.
5
Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids.内体逃逸与核定位：治疗性核酸的关键障碍
Molecules. 2024 Dec 19;29(24):5997. doi: 10.3390/molecules29245997.
6
Host Factor Rab4b Promotes Replication.宿主因子Rab4b促进复制。
Microorganisms. 2024 Aug 31;12(9):1804. doi: 10.3390/microorganisms12091804.
7
Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy.ARF6 介导的肿瘤内在内膜运输塑造了免疫抑制微环境，促进了黑色素瘤的发生发展以及对检查点阻断治疗的反应。
Nat Commun. 2024 Aug 4;15(1):6613. doi: 10.1038/s41467-024-50881-1.
8
The ADP-Ribosylation Factor 6 Plays an Essential Role in Abiotic Stress Response and Fungal Virulence to Host Plants.ADP核糖基化因子6在植物非生物胁迫响应及真菌对寄主植物的致病性中起关键作用。
J Fungi (Basel). 2023 Dec 25;10(1):12. doi: 10.3390/jof10010012.
9
ARF6-dependent endocytic trafficking of the Interferon-γ receptor drives adaptive immune resistance in cancer.依赖ARF6的干扰素-γ受体胞吞运输驱动癌症中的适应性免疫抵抗。
bioRxiv. 2023 Oct 2:2023.09.29.560199. doi: 10.1101/2023.09.29.560199.
10
The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications.内吞作用的化学抑制剂：从机制到潜在的临床应用。
Cells. 2023 Sep 19;12(18):2312. doi: 10.3390/cells12182312.
本文引用的文献
1
Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.上皮性囊肿中未调节的 ARF6 激活产生超活跃的信号转导内体，并破坏形态发生。
Mol Biol Cell. 2010 Jul 1;21(13):2355-66. doi: 10.1091/mbc.e09-09-0824. Epub 2010 May 12.
2
A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody.分离酶在调控有丝分裂沟和中体处 RAB-11 阳性囊泡中的作用。
Curr Biol. 2010 Feb 9;20(3):259-64. doi: 10.1016/j.cub.2009.12.045. Epub 2010 Jan 28.
3
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.Armus 是 Rac1 的效应物，可使 Rab7 失活并调节 E-钙黏蛋白降解。
Curr Biol. 2010 Feb 9;20(3):198-208. doi: 10.1016/j.cub.2009.12.053. Epub 2010 Jan 28.
4
FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.FRMD4A 通过将 Arf6 的激活与 PAR 复合物连接起来调节上皮细胞极性。
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):748-53. doi: 10.1073/pnas.0908423107. Epub 2009 Dec 22.
5
Metastasis: wherefore arf thou?转移：汝在何方？
Curr Biol. 2009 Dec 1;19(22):R1036-8. doi: 10.1016/j.cub.2009.10.032.
6
Endosomal recycling regulation during cytokinesis.胞质分裂过程中的内体循环调控。
Commun Integr Biol. 2009 Sep;2(5):444-7. doi: 10.4161/cib.2.5.8931.
7
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles.ARF6 调节肿瘤细胞来源的质膜微囊泡的释放。
Curr Biol. 2009 Dec 1;19(22):1875-85. doi: 10.1016/j.cub.2009.09.059. Epub 2009 Nov 5.
8
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.Slit2-Robo4信号通路通过阻断Arf6活性来促进血管稳定性。
Nat Cell Biol. 2009 Nov;11(11):1325-31. doi: 10.1038/ncb1976. Epub 2009 Oct 18.
9
The molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis.载脂蛋白介导的细胞脂质平衡的 HDL 及其相关囊泡运输机制的分子机制。
Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1718-22. doi: 10.1161/ATVBAHA.108.179507.
10
Cytokinetic abscission: cellular dynamics at the midbody.细胞分裂期胞质分裂：中体处的细胞动力学
Trends Cell Biol. 2009 Nov;19(11):606-16. doi: 10.1016/j.tcb.2009.07.008. Epub 2009 Sep 3.
Zotero 插件