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微波辅助合成及 2-喹喔啉酮-3-腙衍生物的抗菌活性。

Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives.

机构信息

Chemistry Department, Covenant University, Canaanland, PMB 1023 Ota, Ogun State, Nigeria.

出版信息

Bioorg Med Chem. 2010 Jan 1;18(1):214-21. doi: 10.1016/j.bmc.2009.10.064. Epub 2009 Nov 6.

DOI:10.1016/j.bmc.2009.10.064
PMID:19948407
Abstract

A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 3-{2-[1-(6-chloro-2-oxo-2H-chromen-3-yl)ethylidene]hydrazinyl}quinoxalin-2(1H)-one, 7 while 3-[2-(propan-2-ylidene)hydrazinyl]quinoxalin-2(1H)-one, 2 appeared to be the most active antifungal agent.

摘要

已经开发出一种使用微波辐射技术合成各种 2-喹喔啉酮-3-腙衍生物的简单高效方法。通过分析和光谱数据对合成的一系列 2-喹喔啉酮-3-腙衍生物进行了结构确证，并对其进行了抗菌活性评价。结果表明，该骨架结构表现出作为抗菌剂的显著功效。最有效的抗菌剂是 3-{2-[1-(6-氯-2-氧代-2H-色烯-3-基)亚乙基]肼基}喹喔啉-2(1H)-酮 7，而 3-[2-(丙烷-2-亚基)肼基]喹喔啉-2(1H)-酮 2 似乎是最有效的抗真菌剂。

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