Department of Neurology, Semmelweis University, Balassa u. 6., H-1083 Budapest, Hungary.
Parkinsonism Relat Disord. 2010 May;16(4):290-3. doi: 10.1016/j.parkreldis.2009.11.006. Epub 2009 Nov 30.
One of the most prevalent neurological disorders is Parkinson's disease (PD), characterized by four cardinal signs: tremor, bradykinesia, rigor and postural instability. Although individual signs of Parkinson's disease - most frequently tremor - have been described since ancient times, the first systematic description of the disease is attributed to James Parkinson in 1817. Here we present evidence that not only individual signs, but the disease itself with all four cardinal signs were described in 1690 by Ferenc Pápai Páriz, in a Hungarian medical text over 120 years before the classical description of James Parkinson. In this article I draw the reader's attention to the descriptive chapter in Pápai's book that was published in Hungarian, which because it is understood by so few people, has resulted in this description of PD being ignored in the medical literature.
帕金森病（PD）是最常见的神经退行性疾病之一，其特征为四大主征：震颤、运动迟缓、肌强直和姿势不稳。尽管帕金森病的个别症状（最常见的是震颤）自古就有描述，但该疾病的首次系统描述可追溯到 1817 年的 James Parkinson。在此，我们提出证据表明，早在 James Parkinson 经典描述的 120 多年前， Ferenc Pápai Páriz 就在 1690 年的一篇匈牙利医学文献中，对该病进行了描述，不仅描述了个别症状，还描述了具有四大主征的疾病本身。在本文中，我提请读者注意 Pápai 书中的描述章节，由于该书仅被少数人理解，因此导致这一帕金森病描述在医学文献中被忽视。
