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以白虎汤治疗硝苯地平致大鼠牙龈增生。

Therapy for nifedipine-induced gingival overgrowth by Saireito in rats.

机构信息

Department of Dental Pharmacology, Matsumoto Dental University, 1780 Hirooka-Gohbara, Shiojiri 399-0781, Japan.

出版信息

Eur J Med Res. 2009 Nov 3;14(11):497-501. doi: 10.1186/2047-783x-14-11-497.

DOI:10.1186/2047-783x-14-11-497
PMID:19948446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3352291/
Abstract

OBJECTIVE

A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Saireito has a therapeutic use in the treatment of nifedipine-induced gingival overgrowth.

METHODS

The rats had significant gingival overgrowth induced by the administration of nifedipine. The space between the submandibular incisors and the width of buccal gingiva of maxillary left first molar were macroscopically measured. The buccal gingiva was microscopically examined.

RESULTS

Eight weeks after Saireito was administrated together with nifedipine, Saireito decreased both the incisor space and the gingiva width which had been enlarged by nifedipine and furthermore, the area of connective tissue of nifedipine + Saireito group was significantly smaller than that of nifedipine alone.

CONCLUSION

In conclusion, Saireito may be clinically effective in therapy for calcium antagonist-induced gingival overgrowth.

摘要

目的

钙拮抗剂硝苯地平会引起牙龈增生等副作用。已证实日本传统药物薬味增甘汤能抑制硝苯地平诱导的牙龈成纤维细胞的增殖。我们进行了一项体内实验，以确定薬味增甘汤是否可用于治疗硝苯地平引起的牙龈增生。

方法

通过给予硝苯地平，大鼠出现明显的牙龈增生。宏观测量下颌切牙之间的间隙和上颌左第一磨牙颊侧牙龈的宽度。对颊侧牙龈进行组织学检查。

结果

硝苯地平与薬味增甘汤联合使用 8 周后，与单独使用硝苯地平相比，薬味增甘汤降低了由硝苯地平引起的切牙间隙和牙龈宽度的增大，并且硝苯地平+薬味增甘汤组的结缔组织面积明显小于硝苯地平组。

结论

总之，薬味增甘汤可能对钙拮抗剂引起的牙龈增生具有临床疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/63fe437c81b1/2047-783X-14-11-497-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/cfb06e799ced/2047-783X-14-11-497-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/425904847e84/2047-783X-14-11-497-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/db63579bef69/2047-783X-14-11-497-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/63fe437c81b1/2047-783X-14-11-497-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/cfb06e799ced/2047-783X-14-11-497-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/425904847e84/2047-783X-14-11-497-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/db63579bef69/2047-783X-14-11-497-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a88/3352291/63fe437c81b1/2047-783X-14-11-497-4.jpg

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本文引用的文献

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Inhibition of nifedipine-induced proliferation of cultured human gingival fibroblasts by Saiko, a Chinese herbal medicine.
Phytother Res. 2006 Aug;20(8):704-7. doi: 10.1002/ptr.1913.
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Nifedipine-induced vascular endothelial growth factor secretion from coronary smooth muscle cells promotes endothelial tube formation via the kinase insert domain-containing receptor/fetal liver kinase-1/NO pathway.硝苯地平诱导冠状动脉平滑肌细胞分泌血管内皮生长因子，通过激酶插入结构域受体/胎儿肝激酶-1/一氧化氮途径促进内皮细胞管形成。
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Nephron Exp Nephrol. 2005;100(3):e132-42. doi: 10.1159/000085059. Epub 2005 Apr 11.
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Suppressive effects of Sairei-to on mesangial proliferation in a rat model of glomerulonephritis.柴苓汤对肾小球肾炎大鼠模型系膜增生的抑制作用。
Clin Exp Nephrol. 2004 Sep;8(3):216-22. doi: 10.1007/s10157-004-0302-2.
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The herbal medicine Sairei-to inhibits proliferation of rat mesangial cells.
Nephron. 2002;92(3):652-9. doi: 10.1159/000064112.
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Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats.环孢素与硝苯地平联合应用对大鼠牙龈增生影响的形态学评价
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8
Tenidap, an anti-inflammatory agent, inhibits DNA and collagen syntheses, depresses cell proliferation, and lowers intracellular pH in cultured human gingival fibroblasts.
J Pharmacol Exp Ther. 2002 Feb;300(2):668-72. doi: 10.1124/jpet.300.2.668.
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