耐甲氧西林金黄色葡萄球菌 239 型（TW）的新型高传染性、多重抗生素和防腐剂耐药变体的基因组序列。
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
机构信息
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom.
出版信息
J Bacteriol. 2010 Feb;192(3):888-92. doi: 10.1128/JB.01255-09. Epub 2009 Nov 30.
Abstract
The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.
摘要
一株暴发的耐甲氧西林金黄色葡萄球菌（MRSA）菌株（TW20）的 3.1Mb 基因组中含有近期获得的 DNA 的证据，包括两个大型区域（635kb 和 127kb）。由于移动遗传元件编码的耐药基因以及管家基因的突变，该菌株对广泛的抗生素、防腐剂和重金属具有耐药性。
相似文献
1
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
J Bacteriol. 2010 Feb;192(3):888-92. doi: 10.1128/JB.01255-09. Epub 2009 Nov 30.
2
Next-Generation Sequence Analysis Reveals Transfer of Methicillin Resistance to a Methicillin-Susceptible Staphylococcus aureus Strain That Subsequently Caused a Methicillin-Resistant Staphylococcus aureus Outbreak: a Descriptive Study.
J Clin Microbiol. 2017 Sep;55(9):2808-2816. doi: 10.1128/JCM.00459-17. Epub 2017 Jul 5.
3
Chlorhexidine and octenidine use, carriage of qac genes, and reduced antiseptic susceptibility in methicillin-resistant Staphylococcus aureus isolates from a healthcare network.
Clin Microbiol Infect. 2019 Sep;25(9):1154.e1-1154.e7. doi: 10.1016/j.cmi.2018.12.036. Epub 2019 Jan 6.
4
Complete genome sequence of Staphylococcus aureus strain JKD6008, an ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate-level vancomycin resistance.
J Bacteriol. 2010 Nov;192(21):5848-9. doi: 10.1128/JB.00951-10. Epub 2010 Aug 27.
5
Development of a real-time assay to determine the frequency of qac genes in methicillin resistant Staphylococcus aureus.
J Microbiol Methods. 2018 Oct;153:133-138. doi: 10.1016/j.mimet.2018.09.017. Epub 2018 Sep 26.
6
Comparative genomics of community-acquired ST59 methicillin-resistant Staphylococcus aureus in Taiwan: novel mobile resistance structures with IS1216V.
PLoS One. 2012;7(10):e46987. doi: 10.1371/journal.pone.0046987. Epub 2012 Oct 5.
7
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage.
Biol Direct. 2009 Jan 13;4:1. doi: 10.1186/1745-6150-4-1.
8
Molecular characteristics of community-acquired methicillin-resistant Staphylococcus aureus in Hokkaido, northern main island of Japan: identification of sequence types 6 and 59 Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus.
Microb Drug Resist. 2011 Jun;17(2):241-50. doi: 10.1089/mdr.2010.0136. Epub 2011 Mar 13.
9
Exploring the evolution and epidemiology of European CC1-MRSA-IV: tracking a multidrug-resistant community-associated meticillin-resistant clone.
Microb Genom. 2021 Jul;7(7). doi: 10.1099/mgen.0.000601.
10
Detection of staphylococcal cassette chromosome mec-associated DNA segments in multiresistant methicillin-susceptible Staphylococcus aureus (MSSA) and identification of Staphylococcus epidermidis ccrAB4 in both methicillin-resistant S. aureus and MSSA.
Antimicrob Agents Chemother. 2008 Dec;52(12):4407-19. doi: 10.1128/AAC.00447-08. Epub 2008 Oct 13.
引用本文的文献
1
Distribution of , , and genes and determination of genetic relatedness of epidemic methicillin-resistant strains associated with bloodstream infections in southern China.
Front Cell Infect Microbiol. 2025 Jan 30;15:1491658. doi: 10.3389/fcimb.2025.1491658. eCollection 2025.
2
Molecular characterization of the (M)-carrying transposon Tn and plasmids in isolates recovered from swine.
Front Vet Sci. 2024 Oct 23;11:1430398. doi: 10.3389/fvets.2024.1430398. eCollection 2024.
3
Molecular Epidemiology and Comparative Genome Analysis of Clinically-isolated MRSA Strains in Indonesia.
Juntendo Iji Zasshi. 2022 Apr 20;68(2):147-156. doi: 10.14789/jmj.JMJ21-0040-OA. eCollection 2022.
4
Virulence attributes of successful methicillin-resistant lineages.
Clin Microbiol Rev. 2023 Dec 20;36(4):e0014822. doi: 10.1128/cmr.00148-22. Epub 2023 Nov 20.
5
Clonal Complexes Distribution of Isolates from Clinical Samples from the Caribbean Islands.
Antibiotics (Basel). 2023 Jun 14;12(6):1050. doi: 10.3390/antibiotics12061050.
6
Chimeric MerR-Family Regulators and Logic Elements for the Design of Metal Sensitive Genetic Circuits in .
ACS Synth Biol. 2023 Mar 17;12(3):735-749. doi: 10.1021/acssynbio.2c00545. Epub 2023 Jan 11.
7
In Silico Genome-Scale Analysis of Molecular Mechanisms Contributing to the Development of a Persistent Infection with Methicillin-Resistant (MRSA) ST239.
Int J Mol Sci. 2022 Dec 16;23(24):16086. doi: 10.3390/ijms232416086.
8
Antibacterial activity of novel linear polyamines against .
Front Microbiol. 2022 Aug 22;13:948343. doi: 10.3389/fmicb.2022.948343. eCollection 2022.
9
A scalable analytical approach from bacterial genomes to epidemiology.
Philos Trans R Soc Lond B Biol Sci. 2022 Oct 10;377(1861):20210246. doi: 10.1098/rstb.2021.0246. Epub 2022 Aug 22.
10
Minos: variant adjudication and joint genotyping of cohorts of bacterial genomes.
Genome Biol. 2022 Jul 5;23(1):147. doi: 10.1186/s13059-022-02714-x.
本文引用的文献
1
Evolution of MRSA during hospital transmission and intercontinental spread.
Science. 2010 Jan 22;327(5964):469-74. doi: 10.1126/science.1182395.
2
Genomics. Genome project standards in a new era of sequencing.
Science. 2009 Oct 9;326(5950):236-7. doi: 10.1126/science.1180614.
3
Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.
J Bacteriol. 2009 Oct;191(19):5964-75. doi: 10.1128/JB.00352-09. Epub 2009 Jul 31.
4
Staphylococcus epidermidis surface protein I (SesI): a marker of the invasive capacity of S. epidermidis?
J Med Microbiol. 2009 Oct;58(Pt 10):1395-1397. doi: 10.1099/jmm.0.008771-0. Epub 2009 Jun 25.
5
Predominance of the Hungarian clone (ST 239-III) among hospital-acquired meticillin-resistant Staphylococcus aureus isolates recovered throughout mainland China.
J Hosp Infect. 2009 Mar;71(3):245-55. doi: 10.1016/j.jhin.2008.10.029. Epub 2009 Jan 20.
6
Methicillin-resistant Staphylococcus aureus in hospitals in Tbilisi, the Republic of Georgia, are variants of the Brazilian clone.
Eur J Clin Microbiol Infect Dis. 2008 Aug;27(8):757-60. doi: 10.1007/s10096-008-0500-z. Epub 2008 May 15.
7
Molecular correlates of host specialization in Staphylococcus aureus.
PLoS One. 2007 Oct 31;2(10):e1120. doi: 10.1371/journal.pone.0001120.
8
Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
Antimicrob Agents Chemother. 2008 Jan;52(1):45-53. doi: 10.1128/AAC.00534-07. Epub 2007 Oct 22.
9
Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.
J Bacteriol. 2008 Jan;190(1):300-10. doi: 10.1128/JB.01000-07. Epub 2007 Oct 19.
10
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9451-6. doi: 10.1073/pnas.0609839104. Epub 2007 May 21.
Zotero 插件