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本文引用的文献

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Evolution of MRSA during hospital transmission and intercontinental spread.耐甲氧西林金黄色葡萄球菌（MRSA）在医院传播和洲际传播过程中的进化。
Science. 2010 Jan 22;327(5964):469-74. doi: 10.1126/science.1182395.
2
Genomics. Genome project standards in a new era of sequencing.基因组学。测序新时代的基因组计划标准。
Science. 2009 Oct 9;326(5950):236-7. doi: 10.1126/science.1180614.
3
Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.金黄色葡萄球菌中新型遗传元件ICE6013的整合及序列特征
J Bacteriol. 2009 Oct;191(19):5964-75. doi: 10.1128/JB.00352-09. Epub 2009 Jul 31.
4
Staphylococcus epidermidis surface protein I (SesI): a marker of the invasive capacity of S. epidermidis?表皮葡萄球菌表面蛋白I（SesI）：表皮葡萄球菌侵袭能力的标志物？
J Med Microbiol. 2009 Oct;58(Pt 10):1395-1397. doi: 10.1099/jmm.0.008771-0. Epub 2009 Jun 25.
5
Predominance of the Hungarian clone (ST 239-III) among hospital-acquired meticillin-resistant Staphylococcus aureus isolates recovered throughout mainland China.在中国大陆各地收集的医院获得性耐甲氧西林金黄色葡萄球菌分离株中，匈牙利克隆株（ST 239-III）占主导地位。
J Hosp Infect. 2009 Mar;71(3):245-55. doi: 10.1016/j.jhin.2008.10.029. Epub 2009 Jan 20.
6
Methicillin-resistant Staphylococcus aureus in hospitals in Tbilisi, the Republic of Georgia, are variants of the Brazilian clone.格鲁吉亚共和国第比利斯医院中的耐甲氧西林金黄色葡萄球菌是巴西克隆株的变体。
Eur J Clin Microbiol Infect Dis. 2008 Aug;27(8):757-60. doi: 10.1007/s10096-008-0500-z. Epub 2008 May 15.
7
Molecular correlates of host specialization in Staphylococcus aureus.金黄色葡萄球菌宿主特异性的分子关联
PLoS One. 2007 Oct 31;2(10):e1120. doi: 10.1371/journal.pone.0001120.
8
Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.突变的反应调节因子graR负责金黄色葡萄球菌从异质性万古霉素中介耐药性转变为万古霉素中介耐药性。
Antimicrob Agents Chemother. 2008 Jan;52(1):45-53. doi: 10.1128/AAC.00534-07. Epub 2007 Oct 22.
9
Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.金黄色葡萄球菌纽曼菌株的基因组序列及葡萄球菌基因组的比较分析：两个主要致病岛的多态性与进化
J Bacteriol. 2008 Jan;190(1):300-10. doi: 10.1128/JB.01000-07. Epub 2007 Oct 19.
10
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.通过全基因组测序追踪金黄色葡萄球菌中多药耐药性的体内进化
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9451-6. doi: 10.1073/pnas.0609839104. Epub 2007 May 21.

耐甲氧西林金黄色葡萄球菌 239 型（TW）的新型高传染性、多重抗生素和防腐剂耐药变体的基因组序列。

Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).

机构信息

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom.

出版信息

J Bacteriol. 2010 Feb;192(3):888-92. doi: 10.1128/JB.01255-09. Epub 2009 Nov 30.

DOI:10.1128/JB.01255-09
PMID:19948800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2812470/
Abstract

The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

摘要

一株暴发的耐甲氧西林金黄色葡萄球菌（MRSA）菌株（TW20）的 3.1Mb 基因组中含有近期获得的 DNA 的证据，包括两个大型区域（635kb 和 127kb）。由于移动遗传元件编码的耐药基因以及管家基因的突变，该菌株对广泛的抗生素、防腐剂和重金属具有耐药性。