耐甲氧西林金黄色葡萄球菌 239 型（TW）的新型高传染性、多重抗生素和防腐剂耐药变体的基因组序列。
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
机构信息
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom.
出版信息
J Bacteriol. 2010 Feb;192(3):888-92. doi: 10.1128/JB.01255-09. Epub 2009 Nov 30.
Abstract
The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.
摘要
一株暴发的耐甲氧西林金黄色葡萄球菌（MRSA）菌株（TW20）的 3.1Mb 基因组中含有近期获得的 DNA 的证据，包括两个大型区域（635kb 和 127kb）。由于移动遗传元件编码的耐药基因以及管家基因的突变，该菌株对广泛的抗生素、防腐剂和重金属具有耐药性。
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Science. 2010 Jan 22;327(5964):469-74. doi: 10.1126/science.1182395.
2
Genomics. Genome project standards in a new era of sequencing.基因组学。测序新时代的基因组计划标准。
Science. 2009 Oct 9;326(5950):236-7. doi: 10.1126/science.1180614.
3
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J Med Microbiol. 2009 Oct;58(Pt 10):1395-1397. doi: 10.1099/jmm.0.008771-0. Epub 2009 Jun 25.
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6
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7
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