Kraft D, Lode H
Klin Wochenschr. 1979 Feb 15;57(4):195-6. doi: 10.1007/BF01477408.
Elimination of ampicillin and gentamicin by hemofiltration was measured in 5 and 4 patients, respectively, being treated for end stage renal failure. Serum half-life time of ampicillin after a single I.V. dose of 2 g, was found to be 2.97 +/- 0.73 h, and the filtrate concentrations declined parallel to the serum ampicillin levels, as was to be expected. The serum half-life time after a single I.V. dose of 1 mg/kg body weight gentamicin was 3.26 +/- 0.42 h, and considerably shorter than T/2 of gentamicin in conventional hemodialysis, while the filtrate concentrations increased paradoxically with declining serum levels. This could be explained by binding of this aminoglycoside to the polyacrylnitril membrane of the RP 6 dialyser used for hemofiltration.
分别对5例和4例终末期肾衰竭患者进行血液滤过清除氨苄西林和庆大霉素的测定。单次静脉注射2g氨苄西林后，血清半衰期为2.97±0.73小时，滤过液浓度与血清氨苄西林水平平行下降，这是预期中的。单次静脉注射1mg/kg体重庆大霉素后的血清半衰期为3.26±0.42小时，明显短于传统血液透析中庆大霉素的半衰期，而滤过液浓度却随着血清水平下降而反常增加。这可以通过该氨基糖苷类药物与用于血液滤过的RP 6透析器的聚丙烯腈膜结合来解释。
