Department of Laboratory Medicine & Pathobiology, University of Toronto, and Hospital for Sick Children, Toronto, Ontario, Canada.
Antimicrob Agents Chemother. 2010 Feb;54(2):945-9. doi: 10.1128/AAC.01316-09. Epub 2009 Nov 30.
We describe the epidemiology of heterogeneously resistant Staphylococcus aureus (hVISA) identified in Canadian hospitals between 1995 and 2006. hVISA isolates were confirmed by the population analysis profiling-area under the curve method. Only 25 hVISA isolates (1.3% of all isolates) were detected. hVISA isolates were more likely to have been health care associated (odds ratio [OR], 5.1; 95% confidence interval [CI], 1.9 to 14.2) and to have been recovered from patients hospitalized in central Canada (OR, 3.0; 95% CI, 1.2 to 7.4). There has been no evidence of vancomycin "MIC creep" in Canadian strains of methicillin (meticillin)-resistant S. aureus, and hVISA strains are currently uncommon.
我们描述了 1995 年至 2006 年间在加拿大医院中发现的异质性万古霉素中介金黄色葡萄球菌(hVISA)的流行病学情况。通过群体分析谱-曲线下面积方法确认 hVISA 分离株。仅检测到 25 株 hVISA 分离株(所有分离株的 1.3%)。hVISA 分离株更可能与医疗保健相关(比值比[OR],5.1;95%置信区间[CI],1.9 至 14.2),并且更可能从加拿大中部住院患者中分离出来(OR,3.0;95%CI,1.2 至 7.4)。加拿大耐甲氧西林金黄色葡萄球菌(meticillin)菌株中没有万古霉素“MIC 攀升”的证据,并且 hVISA 菌株目前并不常见。