Duboc D, Kahan A, Maziere B, Loc'h C, Crouzel C, Menkès C J, Amor B, Strauch G, Guérin F, Syrota A
S. H. Fréderic Joliot, CEA, Orsay, France.
Arthritis Rheum. 1991 Feb;34(2):198-203. doi: 10.1002/art.1780340211.
We assessed the effect of nifedipine on myocardial perfusion and metabolism in 9 patients with systemic sclerosis, using positron emission tomography with a perfusion tracer (potassium-38) and a metabolic tracer (18F-fluorodeoxyglucose [18FDG]). Nifedipine, 20 mg 3 times daily for 1 week, induced a significant increase in 38K myocardial uptake, a significant decrease in 18FDG myocardial uptake, and a significant increase in the myocardial 38K: 18FDG ratio. These results indicate that the increase in myocardial perfusion is associated with modifications in myocardial energy metabolism, which probably result from a beneficial anti-ischemic effect of nifedipine in patients with systemic sclerosis.
我们使用灌注示踪剂（钾-38）和代谢示踪剂（18F-氟脱氧葡萄糖[18FDG]）的正电子发射断层扫描技术，评估了硝苯地平对9例系统性硬化症患者心肌灌注和代谢的影响。硝苯地平，每日3次，每次20mg，服用1周，可使心肌对38K的摄取显著增加，心肌对18FDG的摄取显著减少，心肌38K:18FDG比值显著增加。这些结果表明，心肌灌注的增加与心肌能量代谢的改变有关，这可能是硝苯地平对系统性硬化症患者有益的抗缺血作用所致。
