Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo, Kyoto, Japan.
Reprod Sci. 2010 Apr;17(4):350-7. doi: 10.1177/1933719109353455. Epub 2009 Nov 30.
To investigate the influence of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP).
Six ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes were compared. After hormonal synchronization of the menstrual cycle, artificial insemination (AI) was performed. When pregnancy did not result, ewes were naturally inseminated.
After AI, progesterone concentrations in blood increased and were maintained at >1.0 ng/mL in 9 ewes (3 per group). Three ewes became pregnant after AI. The abortion rate was higher in the UAE group. The remaining 15 sheep were naturally inseminated, with 14 delivering 15 lambs. Mean period of term gestation in UAE group ewes was 155.7 versus 158.6 days in control group ewes. Lambs' body weight, body length, and withers height after birth did not differ between those from UAE group and control group. Lambs from ewes embolized with GP tended to be smaller and had lower body weight than those from other groups.
Uterine artery embolization influenced reproductive ability in sheep and UAE with GP could lead to intrauterine growth retardation.
研究使用三丙烯酰明胶微球（TAGM）或明胶颗粒（GP）双侧子宫动脉栓塞（UAE）对生育能力的影响。
将 6 只接受 TAGM 治疗的母羊、6 只接受 GP 治疗的母羊和 6 只对照母羊进行比较。在月经周期的激素同步后，进行人工授精（AI）。如果没有怀孕，母羊进行自然授精。
AI 后，9 只母羊（每组 3 只）的血液中孕酮浓度升高并维持在>1.0ng/mL。3 只母羊 AI 后怀孕。UAE 组的流产率较高。其余 15 只绵羊进行自然授精，其中 14 只产了 15 只羔羊。UAE 组母羊的平均产程为 155.7 天，对照组为 158.6 天。出生后羔羊的体重、体长和肩高在 UAE 组和对照组之间没有差异。从接受 GP 栓塞的母羊身上产下的羔羊比其他组的羔羊小，体重也较低。
子宫动脉栓塞会影响绵羊的生殖能力，且 GP 治疗的 UAE 可能会导致宫内生长迟缓。
