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羊模型中子宫动脉栓塞后生殖能力的观察:两个季节的观察。

Reproductive ability after uterine artery embolization in a sheep model: observation over 2 seasons.

机构信息

Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii, Kawaramachi-Hirokoji, Kamigyo, Kyoto, Japan.

出版信息

Reprod Sci. 2010 Jul;17(7):679-84. doi: 10.1177/1933719110369010. Epub 2010 May 5.

DOI:10.1177/1933719110369010
PMID:20445009
Abstract

OBJECTIVE

To investigate the mid-term effect of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP).

MATERIALS AND METHODS

Fertility was compared in 6 ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes. All ewes were artificially inseminated or naturally bred for 2 consecutive breeding seasons after UAE. Pregnancies in each breeding season were investigated.

RESULTS

Overall, 36 lambs, all normal in appearance, were delivered after 2 breeding seasons. All 18 ewes delivered lambs in at least the first or second breeding season, with 13 having lambs in both the first and second breeding seasons. In the first breeding season after UAE, all 12 ewes in the UAE group delivered lambs, while 5 (83.3%) of the 6 ewes in the control group did. In the second breeding season, 9 (90%) of the 10 ewes that were alive in the UAE group delivered lambs, while 5 (83.3%) of 6 ewes in the control group did. There were no significant differences in the rate of ewes delivering in the first and second breeding season between control and UAE groups (P = .3333; first season, P > .9999; second season, Fisher exact probability test).

CONCLUSION

The mid-term influence of UAE on reproductive ability in sheep was minimal.

摘要

目的

探讨双侧子宫动脉栓塞术(UAE)后分别使用三丙烯明胶微球(TAGM)和明胶颗粒(GP)对生育能力的中期影响。

材料与方法

比较了 6 只接受 TAGM 栓塞的绵羊、6 只接受 GP 栓塞的绵羊和 6 只对照绵羊的生育能力。所有绵羊在 UAE 后连续两个繁殖季节进行人工授精或自然繁殖。每个繁殖季节都对妊娠情况进行了调查。

结果

经过两个繁殖季节,总共产下了 36 只外观正常的羔羊。18 只母羊至少在第一或第二繁殖季节产羔,其中 13 只母羊在第一和第二繁殖季节都产羔。在 UAE 后的第一个繁殖季节,UAE 组的 12 只母羊全部产羔,而对照组的 6 只母羊中有 5 只(83.3%)产羔。在第二个繁殖季节,UAE 组中存活的 10 只母羊中有 9 只(90%)产羔,而对照组的 6 只母羊中有 5 只(83.3%)产羔。对照组和 UAE 组在第一和第二繁殖季节产羔率无显著差异(P =.3333;第一季节,P >.9999;第二季节,Fisher 确切概率检验)。

结论

UAE 对绵羊生殖能力的中期影响较小。

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