Collaborative Research Resources, School of Medicine, Keio University, 160-8582 Tokyo, Japan.
Adv Exp Med Biol. 2010;658:95-103. doi: 10.1007/978-1-4419-1050-9_10.
Bone cells communicate with each other using various cell surface molecules. Membrane-bound ephrin ligands and Eph tyrosine kinase receptors have been characterized in diverse biological processes, including angiogenesis and neuronal development. Several ephrins and Ephs are expressed in osteoclasts and osteoblasts and regulate bone mineral metabolism through bidirectional signaling into not only receptor-expressing cells but also into ligand-expressing cells. We propose that interaction between ephrinB2-expressing osteoclasts and EphB4-expressing osteoblasts facilitates the transition from bone resorption to bone formation during bone remodeling. Other groups have reported the regulation of ephrinB2 by PTH or PTHrP and the possible involvement of EphB4 in osteoarthritis. It is likely that various ephrins and Ephs mediate interaction among bone cells.
骨细胞通过各种细胞表面分子相互交流。膜结合的 Ephrin 配体和 Eph 酪氨酸激酶受体已在多种生物过程中得到了描述，包括血管生成和神经元发育。几种 Ephrin 和 Eph 在破骨细胞和成骨细胞中表达，并通过双向信号传递调节骨矿物质代谢，不仅作用于受体表达细胞，而且作用于配体表达细胞。我们提出，表达 EphrinB2 的破骨细胞与表达 EphB4 的成骨细胞之间的相互作用促进了骨重建过程中从骨吸收到骨形成的转变。其他研究小组已经报道了 PTH 或 PTHrP 对 EphrinB2 的调节，以及 EphB4 可能参与骨关节炎。很可能各种 Ephrin 和 Eph 介导骨细胞之间的相互作用。
