Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Planta Med. 2010 May;76(7):726-8. doi: 10.1055/s-0029-1240656. Epub 2009 Nov 30.
Two new diterpenes, 4- EPI-triptobenzene L ( 1) and 12- O-deacetyl-6- O-acetyl-19- acetyloxycoleon Q ( 2), as well as eight known diterpenes ( 3- 10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC (50) 4.70, 2.90, 3.03, and 7.20 microg/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 microg/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC (50) 4.43 microg/mL).
从兰屿罗勒的地上部分分离得到了两个新的二萜类化合物，4-EPI-三甲苯 L（1）和 12-O-去乙酰基-6-O-乙酰基-19-乙酰氧基 coleon Q（2），以及 8 个已知的二萜类化合物（3-10）。根据光谱证据确定了分离化合物的结构。化合物 1、2、5 和 10 对恶性疟原虫（IC（50）分别为 4.70、2.90、3.03 和 7.20μg/ml）表现出抗疟原虫活性，而化合物 3、5 和 7 对结核分枝杆菌（MIC 50μg/ml）表现出抗分枝杆菌活性。此外，只有 10 对 NCI-H187 细胞表现出很强的细胞毒性（IC（50）为 4.43μg/ml）。
