Mongkolvisut Wantana, Sutthivaiyakit Somyote
Department of Chemistry, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok, Thailand.
J Nat Prod. 2007 Sep;70(9):1434-8. doi: 10.1021/np070174v. Epub 2007 Sep 11.
Six new poly-O-acylated jatrophane diterpenes (1- 6) have been isolated along with five known compounds from the white latex of Pedilanthus tithymaloides. The structural identification was accomplished on the basis of 2D NMR and MS investigations. Some of these highly oxygenated jatrophane diterpenes possess a rare O-acetyl enol moiety. Compounds 1 and 3- 5 showed antiplasmodial activity with IC(50) values of 3.4-4.4 microg/mL and antimycobacterial activity against Mycobacterium tuberculosis with minimum inhibition concentration (MIC) values ranging from 12.5 to 100 microg/mL.
从红雀珊瑚的白色乳汁中分离出六种新的多-O-酰化麻疯树烷二萜（1-6）以及五种已知化合物。通过二维核磁共振和质谱研究完成了结构鉴定。这些高度氧化的麻疯树烷二萜中的一些含有罕见的O-乙酰基烯醇部分。化合物1和3-5表现出抗疟活性，IC（50）值为3.4-4.4微克/毫升，对结核分枝杆菌具有抗分枝杆菌活性，最低抑菌浓度（MIC）值范围为12.5至100微克/毫升。
