Judge Andy, Welton Nicky J, Sandhu Jat, Ben-Shlomo Yoav
University of Bristol, Bristol, UK.
Arthritis Rheum. 2009 Dec 15;61(12):1657-66. doi: 10.1002/art.24892.
To explore inequalities in the need for hip/knee replacement surgery using a 2-stage cross-cohort approach.
In the first stage, a small-area population-based survey, the Somerset and Avon Survey of Health, was used to provide a high-quality measure of need for hip/knee replacement using the New Zealand (NZ) score. Receiver operating characteristic curve analyses were used to validate a simplified NZ score, excluding information from clinical examination. In the second stage, a nationally representative population-based survey, the English Longitudinal Study of Ageing, was used to explore inequalities in need for hip/knee replacement using the simplified NZ score. Multilevel Poisson regression modeling was used to estimate rates of need for surgery. Exposures considered were age, sex, social class, ethnicity, obesity, Index of Multiple Deprivation 2004 deprivation quintiles, rurality, and ethnic mix of area.
Rates of need for hip/knee replacement increase with age and are lower in men than in women (rate ratio [RR] 0.7, 95% confidence interval [95% CI] 0.6-0.9 for hips; RR 0.8, 95% CI 0.7-1.0 for knees). Those of lowest social class have greater need. Need was greatest for people living in more deprived areas. Individual ethnic group did not predict the need for surgery. For hip replacement, there was no rurality effect; for knee replacement, those in town and fringe areas had greater need. Obesity was a strong predictor of need for surgery (RR 2.3, 95% CI 1.9-2.8 for hips; RR 2.4, 95% CI 2.0-2.8 for knees).
This study provides evidence of greater variations of inequalities in need for hip/knee replacement than previous studies. Further research should explore geographic variation and produce small-area estimates of need to inform local health planning. It is important to complement data on need with willingness to undergo surgery.
采用两阶段交叉队列研究方法,探讨髋关节/膝关节置换手术需求方面的不平等现象。
在第一阶段,开展了一项基于小区域人群的调查,即萨默塞特和埃文健康调查,使用新西兰(NZ)评分法对髋关节/膝关节置换手术需求进行高质量评估。采用受试者工作特征曲线分析来验证简化的NZ评分,该评分排除了临床检查信息。在第二阶段,开展了一项具有全国代表性的基于人群的调查,即英国老龄化纵向研究,使用简化的NZ评分来探讨髋关节/膝关节置换手术需求方面的不平等现象。采用多水平泊松回归模型来估计手术需求率。所考虑的暴露因素包括年龄、性别、社会阶层、种族、肥胖、2004年多重剥夺指数的剥夺五分位数、农村地区以及地区的种族构成。
髋关节/膝关节置换手术的需求率随年龄增长而增加,男性低于女性(髋关节:率比[RR]为0.7,95%置信区间[95%CI]为0.6 - 0.9;膝关节:RR为0.8,95%CI为0.7 - 1.0)。社会阶层最低的人群需求更大。生活在更贫困地区的人群需求最大。个体种族群体并不能预测手术需求。对于髋关节置换手术,不存在农村地区效应;对于膝关节置换手术,城镇和边缘地区的人群需求更大。肥胖是手术需求的一个强有力预测因素(髋关节:RR为2.3,95%CI为1.9 - 2.8;膝关节:RR为2.4,95%CI为2.0 - 2.8)。
本研究提供的证据表明,与以往研究相比,髋关节/膝关节置换手术需求方面的不平等现象存在更大差异。进一步的研究应探索地理差异,并生成小区域的需求估计值,以为地方卫生规划提供信息。将需求数据与接受手术的意愿相结合很重要。