Cao Yu-Tang, Zhao Dan, Yang Sen, Wang Xiao-Yi, Gao Qing-Hong, Xuan Ming, Cao Jing-Fang
Department of Head and Neck Oncology, West China Stomatological Hospital, Sichuan University, Chengdu, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Sep;40(5):881-4.
To study the expression and significance of basic fibroblast growth factor(bFGF)and transforming growth factor-beta 1 (TGF-beta1) in mucoepidermoid carcinomas with different malignant degree.
Using immunohistochemistry (IHC) staining technique, bFGF and TGF-beta1 proteins in the mucoepidermoid carcinoma tissues with different malignant degree, including well-differentiated, moderately differentiated and poorly differentiated mucoepidermoid carcinoma, and normal salivary gland tissue were detected.
The positive rate of bFGF and TGF-beta1 in normal salivary glands were apparently lower than those in malignant mucoepidermoid carcinomas (P<0.05). The positive rate of bFGF in moderately and poorly differentiated mucoepidermoid carcinoma was higher than that in the well-differentiated carcinoma (P <0.05). However, the positive expression of bFGF showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinomas. The positive rate of TGF-beta1 in moderately and poorly differentiated mucoepidermoid carcinomas was lower than that in the well-differentiated carcinoma (P<0.05). The positive expression of TGF-beta1 showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinomas. The expression of bFGF and TGF-beta1 showed negative correlation (r=- 0.471, P=0.0003).
The expression of TGF-beta1 may inhibit the development of the mucoepidermoid carcinoma, contrariwise, the expression of bFGF may prompt the development of the mucoepidermoid carcinoma. The expression of bFGF and TGF-beta1 has a negative correlation.
研究碱性成纤维细胞生长因子（bFGF）和转化生长因子-β1（TGF-β1）在不同恶性程度黏液表皮样癌中的表达及意义。
采用免疫组织化学（IHC）染色技术，检测不同恶性程度的黏液表皮样癌组织（包括高分化、中分化和低分化黏液表皮样癌）及正常涎腺组织中bFGF和TGF-β1蛋白。
正常涎腺组织中bFGF和TGF-β1的阳性率明显低于恶性黏液表皮样癌组织（P<0.05）。中分化和低分化黏液表皮样癌中bFGF的阳性率高于高分化癌（P<0.05）。然而，中分化和低分化黏液表皮样癌之间bFGF的阳性表达无相关性。中分化和低分化黏液表皮样癌中TGF-β1的阳性率低于高分化癌（P<0.05）。中分化和低分化黏液表皮样癌之间TGF-β1的阳性表达无相关性。bFGF与TGF-β1的表达呈负相关（r=-0.471，P=0.0003）。
TGF-β1的表达可能抑制黏液表皮样癌的发展，相反，bFGF的表达可能促进黏液表皮样癌的发展。bFGF与TGF-β1的表达呈负相关。
