PGP9.5在进展期胃癌中的甲基化频率较低。

PGP9.5 was less frequently methylated in advanced gastric carcinoma.

作者信息

Mizukami Hirohi, Goto Tetsuhiro, Kitamura Youhei, Sakata Makiko, Saito Mitsuo, Ishibashi Kazuyoshi, Kigawa Gaku, Nemoto Hiroshi, Sanada Yutaka, Hibi Kenji

机构信息

Department of Surgery, Showa University Fujigaoka Hospital, Aoba-ku, Yokohama 227-8501, Japan.

出版信息

Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1576-9.

PMID:19950834

Abstract

BACKGROUND/AIMS: Recently, it was examined the methylation status of the Protein Gene Product 9.5 (PGP9.5) gene in primary tumors derived from 49 patients with colorectal cancer and evaluated the correlation between the methylation status and the clinicopathological findings. A significant difference was observed in lymph node metastasis (p = 0.029), suggesting that PGP9.5 was less frequently methylated in metastatic colorectal cancer. This result prompted us to examine the methylation status of the PGP9.5 gene in gastric cancers.

METHODOLOGY

It was examined the methylation status of the PGP9.5 gene in primary tumors derived from 30 patients with gastric cancer using qMSP and evaluated the correlation between the methylation status and the clinicopathological findings.

RESULTS

Aberrant methylation of the PGP9.5 gene was detected in 5 of 30 (17%) primary gastric cancers. The present results suggested that the aberrant methylation of the PGP9.5 gene was frequently observed in gastric cancers. Subsequently, clinicopathological data were correlated with the methylation results. A significant difference was observed in extent of tumor, lymph node metastasis, and TNM stage (p = 0.034, 0.015, and 0.028, respectively).

CONCLUSION

PGP9.5 was less frequently methylated in advanced gastric cancer compared to earlier one.

摘要

背景/目的：最近，研究了49例结直肠癌患者原发肿瘤中蛋白质基因产物9.5（PGP9.5）基因的甲基化状态，并评估了甲基化状态与临床病理结果之间的相关性。在淋巴结转移方面观察到显著差异（p = 0.029），这表明PGP9.5在转移性结直肠癌中甲基化频率较低。这一结果促使我们研究胃癌中PGP9.5基因的甲基化状态。