Department of Chemistry, The Scripps Research Institute.
J Org Chem. 2009 Dec 4;74(23):8935-8. doi: 10.1021/jo902039a.
A cinchona alkaloid-catalyzed, highly enantioselective, alpha-amination of oxindoles has been developed. The reaction is general, operationally simple, and affords the desired products in high yields with good to excellent enantioselectivity. Significantly, this study provides a general catalytic method for the construction of a C-N bond at the C3 position of oxindoles as well as for the creation of a nitrogen-containing, tetrasubstituted chiral center.
一种金鸡纳生物碱催化的高对映选择性的氧化吲哚α-胺化反应已被开发出来。该反应具有普遍性、操作简单的特点，以高收率和良好到优秀的对映选择性得到所需产物。值得注意的是，该研究为在氧化吲哚的 C3 位构建 C-N 键以及为构建含氮的四取代手性中心提供了一种通用的催化方法。
