Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver BC V6T 1Z1, Canada.
J Org Chem. 2009 Dec 4;74(23):9140-51. doi: 10.1021/jo9018705.
The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl)methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.
介绍了 4-乙酯基-5-甲基-2-（苯磺酰基）甲基恶唑的制备及其在更复杂恶唑类化合物的合成中的应用。独特天然产物 siphonazoles A 和 B 的全合成，展示了该砌块的应用。还讨论了 siphonazoles 的生物活性。
