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来自捕食性细菌的抗生素。

Antibiotics from predatory bacteria.

作者信息

Korp Juliane, Vela Gurovic María S, Nett Markus

机构信息

Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Beutenbergstr. 11, 07745 Jena, Germany.

Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS) -CONICET- Carrindanga Km 11, Bahía Blanca 8000, Argentina.

出版信息

Beilstein J Org Chem. 2016 Mar 30;12:594-607. doi: 10.3762/bjoc.12.58. eCollection 2016.

DOI:10.3762/bjoc.12.58
PMID:27340451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4902038/
Abstract

Bacteria, which prey on other microorganisms, are commonly found in the environment. While some of these organisms act as solitary hunters, others band together in large consortia before they attack their prey. Anecdotal reports suggest that bacteria practicing such a wolfpack strategy utilize antibiotics as predatory weapons. Consistent with this hypothesis, genome sequencing revealed that these micropredators possess impressive capacities for natural product biosynthesis. Here, we will present the results from recent chemical investigations of this bacterial group, compare the biosynthetic potential with that of non-predatory bacteria and discuss the link between predation and secondary metabolism.

摘要

以其他微生物为食的细菌在环境中普遍存在。虽然其中一些微生物是单独行动的猎手，但其他一些则在攻击猎物之前会聚集形成大型群体。轶事报道表明，采用这种狼群策略的细菌将抗生素用作捕食武器。与这一假设一致的是，基因组测序显示这些微型捕食者具有令人印象深刻的天然产物生物合成能力。在这里，我们将展示对这一细菌群体最近化学研究的结果，将其生物合成潜力与非捕食性细菌的进行比较，并讨论捕食与次级代谢之间的联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/fd3bd22ed225/Beilstein_J_Org_Chem-12-594-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/2e4e71e68962/Beilstein_J_Org_Chem-12-594-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/395045dec12a/Beilstein_J_Org_Chem-12-594-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/7c6e26d72c48/Beilstein_J_Org_Chem-12-594-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/4e9a45d7b100/Beilstein_J_Org_Chem-12-594-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/48bd603676e7/Beilstein_J_Org_Chem-12-594-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/fd3bd22ed225/Beilstein_J_Org_Chem-12-594-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/2e4e71e68962/Beilstein_J_Org_Chem-12-594-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/395045dec12a/Beilstein_J_Org_Chem-12-594-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/7c6e26d72c48/Beilstein_J_Org_Chem-12-594-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/4e9a45d7b100/Beilstein_J_Org_Chem-12-594-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/48bd603676e7/Beilstein_J_Org_Chem-12-594-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c71/4902038/fd3bd22ed225/Beilstein_J_Org_Chem-12-594-g007.jpg

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