Institute of Pesticide, Hunan Agricultural University, Changsha 410128, China.
Org Biomol Chem. 2010 May 21;8(10):2320-2. doi: 10.1039/c000268b.
A series of new chiral phosphine-phosphoramidite ligands with a 3,3'-substituted binaphthyl moiety were prepared from 1-phenylethylamine, and successfully applied in the Rh-catalyzed asymmetric hydrogenation of beta-(acylamino)-acrylates. The research disclosed that the substituents on the 3,3'-positions of binaphthyl moiety significantly influenced the enantioselectivity.
一系列具有 3,3'-取代联萘基部分的新型手性膦-磷酰胺配体由 1-苯乙胺制备，并成功应用于 Rh 催化的β-(酰氨基)-丙烯酰胺的不对称氢化反应。研究表明，联萘基部分的 3,3'-位取代基对对映选择性有显著影响。
