Departament of Gynecology and Oncology, Collegium Medicum Jagiellonian University of Kraków, Poland.
Curr Stem Cell Res Ther. 2010 Mar;5(1):57-62. doi: 10.2174/157488810790442840.
A critical mechanism to maintain urinary continence in women and men is the striated muscle sphincter (rhabdosphincter) that forms a ring around the mid urethra. Cellular therapy and the use of stem cells transplanted into the site of the rhabdosphincter in a setting of stress urinary incontinence may augment sphincter regeneration. Implanted cells may also release trophic factors promoting muscle and nerve integration into this muscle. We hereby review the use of cellular therapy for SUI and our experience with the development of muscle-derived stem cells.
维持女性和男性尿控的一个关键机制是围绕着尿道中段的横纹肌括约肌（rhabdosphincter）。细胞疗法和将干细胞移植到压力性尿失禁的横纹肌括约肌部位可能会增强括约肌再生。植入的细胞还可能释放营养因子，促进肌肉和神经整合到该肌肉中。在此，我们综述了细胞疗法在 SUI 中的应用以及我们在肌源性干细胞开发方面的经验。
