Wang Hung-Jen, Chuang Yao-Chi, Chancellor Michael B
Department of Urology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Int Urogynecol J. 2011 Sep;22(9):1075-83. doi: 10.1007/s00192-011-1432-1. Epub 2011 Apr 20.
Stress urinary incontinence (SUI) is highly prevalent and associated with a reduced quality of life. An intact rhabdosphincter at the mid-urethra is mandatory to maintain urinary continence. Adult stem cell injection therapy for the regenerative repair of an impaired sphincter is currently at the forefront of incontinence research. The implanted cells will fuse with muscle and release trophic factors promoting nerve and muscle integration. Hereby, we review the use of mesenchymal stem cell therapy for SUI and the experience with the development of muscle-derived stem cells.
压力性尿失禁（SUI）非常普遍，且与生活质量下降相关。尿道中段完整的横纹括约肌是维持尿失禁的必要条件。用于受损括约肌再生修复的成体干细胞注射疗法目前处于尿失禁研究的前沿。植入的细胞将与肌肉融合并释放促进神经和肌肉整合的营养因子。在此，我们综述间充质干细胞疗法在压力性尿失禁中的应用以及肌肉衍生干细胞的开发经验。
