Li Yan-hong, Ma Hua-mei, Chen Hong-shan, Su Zhe, Gu Yu-fen, Du Min-lian
Department of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Zhonghua Er Ke Za Zhi. 2009 Jun;47(6):410-5.
To investigate the pattern of pubertal development in healthy Cantonese schoolgirls.
From 1992 to 2001, 311 normal Cantonese schoolgirls, ages from 6.25 to 8.83 yrs (7.24 +/- 0.38) at baseline, were followed up until they reached their final adult height (age 15.72 +/- 0.84 yrs, n = 238). Annual physical examinations including height and weight measurement were performed. From the 3rd visit, pubertal maturations (breast and pubic hair development) were also assessed annually until they were 14.5 years. Age of menarche was recorded.
(1) Median age at the entry of puberty (age at reaching B2) was 9.83 years (9.33-10.33). Median age at initiation of pubic hair development (PH2) was 10.67 (9.92-11.38) years. Menarche occurred at (12.35 +/- 1.30) years. The age at reaching B2, age at reaching PH2 and age of menarche were all later than that observed in the cross-section study performed in 2003, Guangzhou, China. Peak height velocity (PHV) was reached at (10.52 +/- 1.07) years, 1.00 (0.50-1.50) years after B2 was reached. Interval between "age at onset of breast development" and "age at menarche" was 2.92 (2.08-3.67) years. Duration of pubertal growth (defined as the time from age at B2 to age at which adult height was attained) was (4.80 +/- 0.85) years. (2) Average final adult height (FAH) was (158.74 +/- 5.74) cm. As compared with the cross-section studies held in Guangzhou, China, the FAH in our study was higher than that observed in 1985 but was lower than that observed in 2003. (3) Multiple linear regression analyses showed that the age reaching B2 was an independent factor associated with the age of menarche. (4) Durations of breast stages, interval between B2 and menarche and duration of pubertal growth were similar to that reported in the longitudinal studies in the United Kingdom (1969), Senegal (1995-2000), the United States (1986-1996).
In healthy Cantonese schoolgirls, the timing of sexual maturation was in a trend of decline in the past 20 years, however it may have no significant impacts on the tempo of pubertal development and FAH.
研究健康粤语地区女学生的青春期发育模式。
1992年至2001年，对311名正常粤语地区女学生进行随访，基线年龄为6.25至8.83岁（7.24±0.38），直至她们达到最终成人身高（年龄15.72±0.84岁，n = 238）。每年进行包括身高和体重测量在内的体格检查。从第三次就诊开始，每年还评估青春期成熟情况（乳房和阴毛发育），直至14.5岁。记录初潮年龄。
（1）青春期开始的中位年龄（达到B2的年龄）为9.83岁（9.33 - 10.33）。阴毛开始发育（PH2）的中位年龄为10.67（9.92 - 11.38）岁。初潮发生在（12.35±1.30）岁。达到B2的年龄、达到PH2的年龄和初潮年龄均晚于2003年在中国广州进行的横断面研究中观察到的结果。身高增长高峰速度（PHV）在（10.52±1.07）岁时达到，在达到B2后1.00（0.50 - 1.50）年。“乳房发育开始年龄”与“初潮年龄”之间的间隔为2.92（2.08 - 3.67）年。青春期生长持续时间（定义为从B2年龄到达到成人身高的年龄）为（4.80±0.85）年。（2）平均最终成人身高（FAH）为（158.74±5.74）厘米。与在中国广州进行的横断面研究相比，我们研究中的FAH高于1985年观察到的结果，但低于2003年观察到的结果。（3）多元线性回归分析表明，达到B2的年龄是与初潮年龄相关的独立因素。（4）乳房分期的持续时间、B2与初潮之间的间隔以及青春期生长的持续时间与英国（1969年）、塞内加尔（1995 - 2000年）、美国（1986 - 1996年）的纵向研究报告相似。
在健康粤语地区女学生中，过去20年性成熟时间呈下降趋势，但可能对青春期发育节奏和FAH没有显著影响。
