Pantos Constantinos, Mourouzis Iordanis
Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece,
Heart Fail Rev. 2015 May;20(3):273-82. doi: 10.1007/s10741-014-9465-4.
Thyroid hormone (TH) appears to have a critical role in cardiac repair after injury beyond its role in development and metabolism homeostasis. This unique action is due to the fact that TH effect on the heart is shown to be differentiated depending on its administration on injured or healthy myocardium. Thus, TH can limit ischemia-reperfusion injury via a fine balance between pro-apoptotic and pro-survival signaling pathways. This response is thyroid hormone receptor (TRα1) dependent. Furthermore, an interaction between stress-induced growth kinase signaling and TRα1 is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. This new evidence is consistent with clinical observations showing the cardioprotective effect of TH treatment in cardiac surgery, transplantation and heart failure. TH and/or thyroid analogs may be novel agents in treating heart diseases.
甲状腺激素（TH）在心脏损伤后的修复中似乎具有关键作用，这超出了其在发育和代谢稳态中的作用。这种独特作用的原因在于，TH对心脏的影响显示出因施用于受损或健康心肌而有所不同。因此，TH可通过促凋亡信号通路和促生存信号通路之间的精细平衡来限制缺血再灌注损伤。这种反应依赖于甲状腺激素受体（TRα1）。此外，应激诱导的生长激酶信号通路与TRα1之间的相互作用被证明会发生，并根据TH的可用性决定缺血后重塑和心脏恢复。这一新证据与临床观察结果一致，这些观察结果表明TH治疗在心脏手术、移植和心力衰竭中具有心脏保护作用。TH和/或甲状腺类似物可能是治疗心脏病的新型药物。
