Wadas Theresa M
Adult Acute Nurse Practitioner Program, School of Nursing, University of Alabama at Birmingham, NB 544, 1530 3rd Avenue South, Birmingham, Alabama 35294-1210, USA.
Crit Care Nurs Clin North Am. 2009 Dec;21(4):493-505. doi: 10.1016/j.ccell.2009.07.010.
Despite newer neuroimaging techniques, timely and accurate diagnosis of acute stroke remains a significant challenge. The ability to identify stroke patients rapidly using a biologic biomarker would be highly beneficial. Inflammation following stroke is one physiologic mechanism that has been studied extensively in biomarker research. Several emerging inflammatory biomarkers have been identified and may be useful to diagnosis stroke, to predict the evolution of stroke, and to predict hemorrhagic transformation, particularly with the administration of thrombolytic therapy. Many challenges must be overcome before application to clinical practice can be recommended. Nevertheless, emerging inflammatory biomarkers demonstrate considerable promise, particularly as part of a multiple biomarker strategy, and significant improvement in stroke diagnosis, clinical management, and outcomes may be realized.
尽管有了更新的神经成像技术，但急性中风的及时准确诊断仍然是一项重大挑战。利用生物标志物快速识别中风患者的能力将非常有益。中风后的炎症是生物标志物研究中广泛研究的一种生理机制。已经确定了几种新兴的炎症生物标志物，它们可能有助于中风的诊断、预测中风的演变以及预测出血性转化，特别是在溶栓治疗的情况下。在推荐应用于临床实践之前，必须克服许多挑战。然而，新兴的炎症生物标志物显示出相当大的前景，特别是作为多种生物标志物策略的一部分，并且可能实现中风诊断、临床管理和治疗结果的显著改善。
