双氯芬酸钠过量致一过性肾功能不全。
Transient renal insufficiency following dipyrone overdose.
机构信息
Pediatric Intensive Care Unit, Assaf Harofeh Medical Center, Zerifi n, Israel.
出版信息
Arch Dis Child. 2010 Mar;95(3):233-4. doi: 10.1136/adc.2009.171793. Epub 2009 Nov 30.
AIM
To describe the incidence of acute renal insufficiency after dipyrone overdose in children.
METHODS
The medical records of all patients < or =18 years of age during a 3-year period presenting at Assaf Harofeh Medical Center due to toxic exposure were retrospectively reviewed. Patients suffering from dipyrone overdose were compared with all the other patients.
RESULTS
235 cases were included in the final analysis. Of these, 26 (11%) patients were exposed to dipyrone (median age 15 years). Three of the 26 patients (12%) had transient non-oliguric renal insufficiency. One other patient who did not receive dipyrone also developed transient renal insufficiency.
CONCLUSIONS
Dipyrone overdose is frequent and may cause acute non-oliguric renal insufficiency. Renal function should be monitored in such patients.
目的
描述儿童扑热息痛过量后急性肾功能不全的发生率。
方法
回顾性分析了 3 年内因中毒暴露而在 Assaf Harofeh 医疗中心就诊的所有<或=18 岁患者的病历。将扑热息痛过量的患者与所有其他患者进行比较。
结果
最终分析纳入 235 例患者。其中 26 例（11%）患者暴露于扑热息痛（中位年龄 15 岁）。26 例患者中有 3 例（12%）出现短暂性非少尿性肾功能不全。另一位未使用扑热息痛的患者也出现了短暂性肾功能不全。
结论
扑热息痛过量很常见，可能导致急性非少尿性肾功能不全。应监测此类患者的肾功能。
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